Geno J. Merli, MD; Howard H. Weitz, MD
Disclosures: Geno J. Merli, MD, and Howard H. Weitz, MD, report that they have no financial relationships or interests to disclose.
Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.
Matthew Thran, MD
Brown - Lifespan, Providence, RI
April 2, 2020
An alternative to early and late PONV might be Transient and Persistent PONV. Regarding medications, a more common alternative H1 blocker that we use is diphenhydramine and an alternative to droperidol that we use is haloperidol (same QT issue but no black box warning). Aprepitant is seeing growing use in colorectal surgery where PONV may have negative effects on the anastamosis and also in patients with strong history of PONV despite usual prophylaxis.
Merli GJ, Weitz HH. Annals Consult Guys - Nausea and Vomiting After Surgery. Ann Intern Med. 2019;171:CG1. doi: https://doi.org/10.7326/W18-0051
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Published: Ann Intern Med. 2019;171(12):CG1.
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