The summary below is from the full report titled “Torsade de Pointes Associated with Very-High-Dose Methadone.” It is in the 17 September 2002 issue of Annals of Internal Medicine (volume 137, pages 501-504). The authors are MJ Krantz, L Lewkowiez, H Hays, MA Woodroffe, AD Robertson, and PS Mehler.
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Very High Doses of Methadone May Cause Abnormal Heart Rhythm. Ann Intern Med. ;137:I–42. doi: 10.7326/0003-4819-137-6-200209170-00004
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Published: Ann Intern Med. 2002;137(6):I-42.
DOI: 10.7326/0003-4819-137-6-200209170-00004
Cardiology, Rhythm Disorders and Devices.
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