Michael A. Steinman, MD; Ralph Gonzales, MD, MSPH; Jeffrey A. Linder, MD, MPH; C. Seth Landefeld, MD
Acknowledgment: The authors thank Eric Vittinghoff, PhD, Division of Epidemiology and Biostatistics, University of California, San Francisco, for his helpful assistance with statistical issues.
Grant Support: By the VA National Quality Scholars Program (Drs. Steinman and Landefeld); the Robert Wood Johnson Foundation Minority Medical Faculty Development Program (Dr. Gonzales); National Research Service Award 5T32PE11001-12 (Dr. Linder); and grants from the National Institute on Aging, the John A. Hartford Foundation, Dartmouth College, and a grant to Dartmouth College from the Pfizer Foundation (Dr. Landefeld).
Potential Financial Conflicts of Interest:Honoraria: R. Gonzales (SmithKline Beecham); Grants received: R. Gonzales (Abbott Laboratories, SmithKline Beecham, and Roche).
Requests for Single Reprints: Michael A. Steinman, MD, Division of Geriatrics, Box 181-G, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121; e-mail, email@example.com.
Current Author Addresses: Drs. Steinman and Landefeld: Division of Geriatrics, Box 181-G, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121.
Dr. Gonzales: Department of Medicine, Box 1211, University of California, San Francisco, San Francisco, CA 94143-1211.
Dr. Linder: Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.
Author Contributions: Conception and design: M.A. Steinman, J.A. Linder.
Analysis and interpretation of the data: M.A. Steinman, R. Gonzales, J.A. Linder, C.S. Landefeld.
Drafting of the article: M.A. Steinman, R. Gonzales, J.A. Linder.
Critical revision of the article for important intellectual content: M.A. Steinman, R. Gonzales, J.A. Linder, C.S. Landefeld.
Final approval of the article: M.A. Steinman, R. Gonzales, J.A. Linder, C.S. Landefeld.
Statistical expertise: M.A. Steinman, R. Gonzales, J.A. Linder.
Collection and assembly of data: M.A. Steinman.
Judicious use of antibiotics can slow the spread of antimicrobial resistance. However, overall patterns of antibiotic use among ambulatory patients are not well understood.
To study patterns of outpatient antibiotic use in the United States, focusing on broad-spectrum antibiotics.
Cross-sectional survey in three 2-year periods (19911992, 19941995, and 19981999).
The National Ambulatory Medical Care Survey, a nationally representative sample of community-based outpatient visits.
Patients visiting community-based outpatient clinics.
Rates of overall antibiotic use and use of broad-spectrum antibiotics (azithromycin and clarithromycin, quinolones, amoxicillinclavulanate, and second- and third-generation cephalosporins). All comparisons were made between the first study period (19911992) and the final study period (19981999).
Between 19911992 and 19981999, antibiotics were used less frequently to treat acute respiratory tract infections, such as the common cold and pharyngitis. However, use of broad-spectrum agents increased from 24% to 48% of antibiotic prescriptions in adults (P < 0.001) and from 23% to 40% in children (P < 0.001). Use of broad-spectrum antibiotics increased across many conditions, increasing two- to threefold as a percentage of total antibiotic use for a variety of diagnoses in both adults and children. By 19981999, 22% of adult and 14% of pediatric prescriptions for broad-spectrum antibiotics were for the common cold, unspecified upper respiratory tract infections, and acute bronchitis, conditions that are primarily viral.
Antibiotic use in ambulatory patients is decreasing in the United States. However, physicians are increasingly turning to expensive, broad-spectrum agents, even when there is little clinical rationale for their use.
Indiscriminate use of antibiotics promotes the development of antibiotic-resistant strains of bacteria.
This survey of patient visits to community-based clinics shows that antibiotic use for ambulatory infections, especially upper respiratory tract infections, decreased from 19911992 to 19981999. However, the use of broad-spectrum antibiotics rose over this period.
Efforts to encourage rational use of antibiotics should focus on which antibiotic to use as well as whether or not to use antibiotics.
Antibiotic prescribing among adults between 19911992 and 19981999.URTIPPPPP
Antibiotic prescribing among children between 19911992 and 19981999.URTIPPP
Use of broad-spectrum antibiotics for selected conditions.UTIURTIPPP
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Steinman MA, Gonzales R, Linder JA, Landefeld CS. Changing Use of Antibiotics in Community-Based Outpatient Practice, 19911999. Ann Intern Med. ;138:525–533. doi: 10.7326/0003-4819-138-7-200304010-00008
Download citation file:
Published: Ann Intern Med. 2003;138(7):525-533.
Infectious Disease, Nephrology, Pulmonary/Critical Care, Urological Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use