Mori J. Krantz, MD; Judith Martin, MD; Barry Stimmel, MD; Davendra Mehta, MD; Mark C.P. Haigney, MD
An independent panel developed cardiac safety recommendations for physicians prescribing methadone.
Expert panel members reviewed and discussed the following sources regarding methadone: pertinent English-language literature identified from MEDLINE and EMBASE searches (1966 to June 2008), national substance abuse guidelines from the United States and other countries, information from regulatory authorities, and physician awareness of adverse cardiac effects.
Clinicians should inform patients of arrhythmia risk when they prescribe methadone.
Clinicians should ask patients about any history of structural heart disease, arrhythmia, and syncope.
Obtain a pretreatment electrocardiogram for all patients to measure the QTc interval and a follow-up electrocardiogram within 30 days and annually. Additional electrocardiography is recommended if the methadone dosage exceeds 100 mg/d or if patients have unexplained syncope or seizures.
If the QTc interval is greater than 450 ms but less than 500 ms, discuss the potential risks and benefits with patients and monitor them more frequently. If the QTc interval exceeds 500 ms, consider discontinuing or reducing the methadone dose; eliminating contributing factors, such as drugs that promote hypokalemia; or using an alternative therapy.
Clinicians should be aware of interactions between methadone and other drugs that possess QT intervalâ€“prolonging properties or slow the elimination of methadone.
Editor's Note: Some members of an expert panel proposed the recommendations presented in this publication. Two panel members declined acknowledgment for the publication. This publication is not a federal guideline. A government agency has recently forwarded draft recommendations related to QTc interval screening in methadone treatment for field review prior to finalization.
CSAT = Center for Substance Abuse and Treatment; QTc = rate- corrected QT interval.
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Krantz MJ, Martin J, Stimmel B, et al. QTc Interval Screening in Methadone Treatment. Ann Intern Med. 2009;150:387–395. doi: 10.7326/0003-4819-150-6-200903170-00103
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Published: Ann Intern Med. 2009;150(6):387-395.
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