Angelo Scuteri, MD, PhD; Angelo J.G. Bos, MD, PhD; Larry J. Brant, PhD; Laura Talbot, EdD, PhD; Edward G. Lakatta, MD; Jerome L. Fleg, MD
Postmenopausal women taking hormone replacement therapy have a smaller increase in systolic blood pressure over time than those not taking this therapy. This difference is intensified at older ages.
Ann Intern Med. 2001;135(4):229-238. doi:10.7326/0003-4819-135-4-200108210-00007
Janet C. Mohle-Boetani, MD, MPH; Jeff A. Farrar, DVM, PhD; S. Benson Werner, MD, MPH; Dzovag Minassian, MPH; Ray Bryant; Sharon Abbott; Laurence Slutsker, MD, MPH; Duc J. Vugia, MD, MPH; for the Investigation Team*
In California, from 1996 through 1998, more than 50% of multicounty outbreaks with confirmed food vehicles were related to alfalfa or clover sprouts. This summary of the investigations of these outbreaks indicates that sprouts can be a hazardous food. Seed and sprout growers should implement measures to decrease contamination, and the general public should recognize the risks of eating sprouts.
Ann Intern Med. 2001;135(4):239-247. doi:10.7326/0003-4819-135-4-200108210-00008
Gabor G. Illei, MD; Howard A. Austin III, MD; Marianna Crane, NP; Lee Collins, MS; Mark F. Gourley, MD; Cheryl H. Yarboro, RN; Ellen M. Vaughan, MSN; Takashi Kuroiwa, MD; Carol L. Danning, MD; Alfred D. Steinberg, MD; John H. Klippel, MD; James E. Balow, MD; Dimitrios T. Boumpas, MD
With extended follow-up, pulse cyclophosphamide continued to show superior efficacy over pulse methylprednisolone alone for treatment of lupus nephritis. The combination of pulse cyclophosphamide and methylprednisolone appears to provide additional benefit over pulse cyclophosphamide alone and does not confer additional risk for adverse events.
Ann Intern Med. 2001;135(4):248-257. doi:10.7326/0003-4819-135-4-200108210-00009
Anna M. Sawka, MD; William F. Young Jr., MD; Geoffrey B. Thompson, MD; Clive S. Grant, MD; David R. Farley, MD; Cynthia Leibson, PhD; Jon A. van Heerden, MD
Resolution of hypertension after adrenalectomy for primary aldosteronism is independently associated with a lack of family history of hypertension and preoperative use of two or fewer antihypertensive agents.
Ann Intern Med. 2001;135(4):258-261. doi:10.7326/0003-4819-135-4-200108210-00010
Jürgen Westermann, MD; Britta Engelhardt, MD; Jörg C. Hoffmann, MD
The authors review the migration of labeled T-cell subsets in unmanipulated animals, discuss the relevance of these findings to the clinical outcome of anti–adhesion-molecule therapy, and outline how these observations may help us better understand T-cell–mediated diseases and develop new therapeutic strategies.
Ann Intern Med. 2001;135(4):279-295. doi:10.7326/0003-4819-135-4-200108210-00013
Ronald C. Kessler, PhD; Roger B. Davis, ScD; David F. Foster, MD; Maria I. Van Rompay, BA; Ellen E. Walters, MS; Sonja A. Wilkey, BA; Ted J. Kaptchuk, OMD; David M. Eisenberg, MD
Although recent research has shown that many people in the United States use complementary and alternative medical (CAM) therapies, little is known about time trends in use. These authors found that use of CAM therapies by a large proportion of the study sample is the result of a secular trend that began at least a half-century ago. This trend suggests a continuing demand for CAM therapies that will affect health care delivery for the foreseeable future.
Ann Intern Med. 2001;135(4):262-268. doi:10.7326/0003-4819-135-4-200108210-00011
Edmund J. Lewis, MD
In this issue, Illei and colleagues report on a clinical trial of lupus nephritis that compared parenteral methylprednisolone, parenteral cyclophosphamide, and a combination of these two treatments, all in addition to low-dose oral prednisone. Their study raised hope that a more definitive answer to ideal therapy is on the horizon. Unfortunately, the study has important limitations.
Ann Intern Med. 2001;135(4):296-298. doi:10.7326/0003-4819-135-4-200108210-00014
Ann Intern Med. 2001;135(4):299. doi:10.7326/0003-4819-135-4-200108210-00015
Ann Intern Med. 2001;135(4):299. doi:10.7326/0003-4819-135-4-200108210-00016
Ann Intern Med. 2001;135(4):299-300. doi:10.7326/0003-4819-135-4-200108210-00017
Ann Intern Med. 2001;135(4):300. doi:10.7326/0003-4819-135-4-200108210-00018
Ann Intern Med. 2001;135(4):300-301. doi:10.7326/0003-4819-135-4-200108210-00019
Ann Intern Med. 2001;135(4):301. doi:10.7326/0003-4819-135-4-200108210-00020
Ann Intern Med. 2001;135(4):301-302. doi:10.7326/0003-4819-135-4-200108210-00021
Ann Intern Med. 2001;135(4):302. doi:10.7326/0003-4819-135-4-200108210-00022
Ann Intern Med. 2001;135(4):302-303. doi:10.7326/0003-4819-135-4-200108210-00023
Ann Intern Med. 2001;135(4):303. doi:10.7326/0003-4819-135-4-200108210-00024
Ann Intern Med. 2001;135(4):303-304. doi:10.7326/0003-4819-135-4-200108210-00025
Ann Intern Med. 2001;135(4):304. doi:10.7326/0003-4819-135-4-200108210-00026
Ann Intern Med. 2001;135(4):304-305. doi:10.7326/0003-4819-135-4-200108210-00027
Ann Intern Med. 2001;135(4):305-306. doi:10.7326/0003-4819-135-4-200108210-00028
Ann Intern Med. 2001;135(4):306. doi:10.7326/0003-4819-135-4-200108210-00029
Ann Intern Med. 2001;135(4):306-307. doi:10.7326/0003-4819-135-4-200108210-00030
Ann Intern Med. 2001;135(4):307. doi:10.7326/0003-4819-135-4-200108210-00031
Ann Intern Med. 2001;135(4):307. doi:10.7326/0003-4819-135-4-200108210-00032
Aaron Levin
Ann Intern Med. 2001;135(4):309-312. doi:10.7326/0003-4819-135-4-200108210-00035
Ann Intern Med. 2001;135(4):I-29. doi:10.7326/0003-4819-135-4-200108210-00003
Ann Intern Med. 2001;135(4):I-30. doi:10.7326/0003-4819-135-4-200108210-00004
Ann Intern Med. 2001;135(4):I-31. doi:10.7326/0003-4819-135-4-200108210-00005
Ann Intern Med. 2001;135(4):I-32. doi:10.7326/0003-4819-135-4-200108210-00006
Ana Marusic, MD, PhD
Ann Intern Med. 2001;135(4):308. doi:10.7326/0003-4819-135-4-200108210-00033
Marshall B. Kapp, JD, MPH
Ann Intern Med. 2001;135(4):308. doi:10.7326/0003-4819-135-4-200108210-00034
Ann Intern Med. 2001;135(4):No Pagination Specified. doi:10.7326/0003-4819-135-4-200108210-00001
John V.L. Sheffield, MD; Eric B. Larson, MD, MPH
This year's Update in General Internal Medicine spans a wide area but fits into a framework of the following themes: hypertension, hormone replacement therapy, anticoagulation, atrial fibrillation, chronic infectious diseases, hospital care, and prevention.
Ann Intern Med. 2001;135(4):269-278. doi:10.7326/0003-4819-135-4-200108210-00012