Andrew T. Chan, MD; Edward L. Giovannucci, MD, ScD; Eva S. Schernhammer, MD, DrPH; Graham A. Colditz, MD, DrPH; David J. Hunter, MD, ScD; Walter C. Willett, MD, DrPH; Charles S. Fuchs, MD, MPH
Taking aspirin regularly is associated with a reduced risk for colorectal adenoma. The greatest effect occurred at substantially higher doses than those recommended for prevention of cardiovascular disease. Before recommending aspirin chemoprevention for all adults, we must understand the risks and benefits of routine aspirin use at these higher doses.
Ann Intern Med. 2004;140(3):157-166. doi:10.7326/0003-4819-140-3-200402030-00006
Jing Chen, MD, MSc; Paul Muntner, PhD; L. Lee Hamm, MD; Daniel W. Jones, MD; Vecihi Batuman, MD; Vivian Fonseca, MD; Paul K. Whelton, MD, MSc; Jiang He, MD, PhD
The metabolic syndrome is defined as 3 or more of the following: hypertension, hyperglycemia, low high-density lipoprotein cholesterol levels, high triglyceride level, and abdominal obesity. The greater the number of these factors, the greater a person's risk for microalbuminuria and chronic kidney disease.
Ann Intern Med. 2004;140(3):167-174. doi:10.7326/0003-4819-140-3-200402030-00007
Daniel J. Quinlan, MBBS; Andrew McQuillan, MBBS; John W. Eikelboom, MBBS
Fixed-dose low-molecular-weight heparin appears to be as effective and safe as dose-adjusted intravenous unfractionated heparin for the initial treatment of pulmonary embolism. This conclusion does not necessarily apply to patients with massive pulmonary embolism because the trials excluded them.
Ann Intern Med. 2004;140(3):175-183. doi:10.7326/0003-4819-140-3-200402030-00008
Jennifer S. Haas, MD, MSPH; Celia P. Kaplan, DrPh, MA; Eric P. Gerstenberger, MS; Karla Kerlikowske, MD
According to this study, more public media attention is associated with greater adoption of clinical research results. The release of the Women's Health Initiative trial results was associated with a greater decline in postmenopausal hormone therapy use than occurred after publication of the Heart and Estrogen/progestin Replacement Study results, which received much less attention from newspapers and television.
Ann Intern Med. 2004;140(3):184-188. doi:10.7326/0003-4819-140-3-200402030-00009
Andrea A. Howard, MD, MS; Julia H. Arnsten, MD, MPH; Marc N. Gourevitch, MD, MPH
Moderate alcohol consumption is associated with a decreased risk for developing diabetes mellitus and a decreased risk for heart disease in persons with diabetes. The long-term effects of alcohol consumption on glycemic control and noncardiac complications in persons with diabetes are poorly understood.
Ann Intern Med. 2004;140(3):211-219. doi:10.7326/0003-4819-140-6-200403160-00011
Penny Whiting, MSc; Anne W.S. Rutjes, MSc; Johannes B. Reitsma, MD, PhD; Afina S. Glas, MD, PhD; Patrick M.M. Bossuyt, PhD; Jos Kleijnen, MD, PhD
Many factors in measuring the sensitivity and specificity of diagnostic tests can lead to biased estimates or variation between studies. Empirical evidence about the size and effect of these issues is limited.
Ann Intern Med. 2004;140(3):189-202. doi:10.7326/0003-4819-140-3-200402030-00010
Carol Levine, MA; Ruth Faden, MPH, PhD; Christine Grady, PhD; Dale Hammerschmidt, MD; Lisa Eckenwiler, PhD; Jeremy Sugarman, MD; on behalf of the Consortium to Examine Clinical Research Ethics
Existing laws and regulations protect research participants. However, some research protocols need additional “special scrutiny” because they create unusual ethical problems. The aim of special scrutiny is full protection for all research participants.
Ann Intern Med. 2004;140(3):220-223. doi:10.7326/0003-4819-140-3-200402030-00013
Robert S. Sandler, MD, MPH
The concept of cancer chemoprevention is tantalizing. If we had a cheap, nontoxic pill that could reduce the risk for cancer, we might reduce the need for surgery or toxic chemotherapy. In this issue, Chan and colleagues provide additional evidence that we may already have such an agent for colorectal cancer. Its identity? Aspirin.
Ann Intern Med. 2004;140(3):224-225. doi:10.7326/0003-4819-140-3-200402030-00014
Lisa M. Schwartz, MD, MS; Steven Woloshin, MD, MS
Over half of U.S. adults report that they follow health news closely. Thus, the press is well positioned to educate the public about health and health risks and what medicine can (and cannot) do. Researchers and medical journals have an obligation to help the media do their job responsibly.
Ann Intern Med. 2004;140(3):226-228. doi:10.7326/0003-4819-140-3-200402030-00015
Cecil G. Helman, MBChB
They sit across the desk from me, the young couple, both tense and distracted. I am very new to family practice, and John is almost exactly the same age as I am. We are the same height and shape, and we have the same style of moustache. We are even dressed in a similar way. But there's a pinched, sallow look about his face, as if the mirror I am peering into is blurred and slightly dusty.
Ann Intern Med. 2004;140(3):229-230. doi:10.7326/0003-4819-140-3-200402030-00017
Ann Intern Med. 2004;140(3):231. doi:10.7326/0003-4819-140-3-200402030-00018
Ann Intern Med. 2004;140(3):231. doi:10.7326/0003-4819-140-3-200402030-00019
Ann Intern Med. 2004;140(3):231-232. doi:10.7326/0003-4819-140-3-200402030-00020
Ann Intern Med. 2004;140(3):232. doi:10.7326/0003-4819-140-3-200402030-00021
Ann Intern Med. 2004;140(3):232-233. doi:10.7326/0003-4819-140-3-200402030-00022
Ann Intern Med. 2004;140(3):233-234. doi:10.7326/0003-4819-140-3-200402030-00023
Ann Intern Med. 2004;140(3):234-235. doi:10.7326/0003-4819-140-3-200402030-00024
Ann Intern Med. 2004;140(3):W-5. doi:10.7326/0003-4819-140-3-200402030-00024-w1
Craig L. Bowron, MD
Ann Intern Med. 2004;140(3):228. doi:10.7326/0003-4819-140-3-200402030-00016
Ann Intern Med. 2004;140(3):I-24. doi:10.7326/0003-4819-140-3-200402030-00001
Ann Intern Med. 2004;140(3):I-39. doi:10.7326/0003-4819-140-3-200402030-00002
Ann Intern Med. 2004;140(3):I-43. doi:10.7326/0003-4819-140-3-200402030-00003
Ann Intern Med. 2004;140(3):I-50. doi:10.7326/0003-4819-140-3-200402030-00004
Ann Intern Med. 2004;140(3):I-72. doi:10.7326/0003-4819-140-3-200402030-00005
Robert Badgett, MD
Ann Intern Med. 2004;140(3):236. doi:10.7326/0003-4819-140-3-200402030-00025
John F. Fisher, MD
Ann Intern Med. 2004;140(3):236. doi:10.7326/0003-4819-140-3-200402030-00026
Ann Intern Med. 2004;140(3):No Pagination Specified. doi:10.7326/0003-4819-140-3-200402030-00028
Elliot Rapaport, MD
This Update focuses on heart failure, acute coronary syndromes, hypertension, and lowering of low-density lipoprotein cholesterol levels. The newer clinical trials in these fields are changing approaches to cardiac care.
Ann Intern Med. 2004;140(3):203-210. doi:10.7326/0003-4819-140-3-200402030-00011
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