Nicholas R. Anthonisen, MD; Melissa A. Skeans, MS; Robert A. Wise, MD; Jure Manfreda, MD; Richard E. Kanner, MD; John E. Connett, PhD; for the Lung Health Study Research Group*
This article provides long-term mortality results of a randomized trial of a smoking cessation program. Only 21.7% in the intervention group had stopped smoking at 5 years (compared with 5.4% of controls). Nonetheless, all-cause mortality per 1000 person-years was 8.83 deaths in the intervention group and 10.38 deaths in the control group. Smoking cessation programs substantially reduce mortality even when only a minority of patients stop smoking.
Ann Intern Med. 2005;142(4):233-239. doi:10.7326/0003-4819-142-4-200502150-00005
Henry Lik-Yuen Chan, MD; Nancy Wai-Yee Leung, MD; Alex Yui Hui, MB, BChir; Vincent Wai-Sun Wong, MBChB; Choong-Tsek Liew, MD; Angel Mei-Ling Chim, BSc; Francis Ka-Leung Chan, MD; Lawrence Cheung-Tsui Hung, MB, BChir; Yuk-Tong Lee, MD; John Siu-Lun Tam, PhD; Christopher Wai-Kei Lam, PhD; Joseph Jao-Yiu Sung, MD, PhD
In patients with hepatitis B e antigen–positive chronic hepatitis B, combination treatment with pegylated interferon-α2b and lamivudine may lead to a higher rate of virologic response than lamivudine monotherapy. The rate of sustained virologic response was 36% for combination therapy and 14% for lamivudine monotherapy.
Ann Intern Med. 2005;142(4):240-250. doi:10.7326/0003-4819-142-4-200502150-00006
Mark D. Schleinitz, MD, MS; Paul A. Heidenreich, MD, MS
In patients with high-risk acute coronary syndromes, 1 year of therapy with clopidogrel plus aspirin followed by life-long aspirin results in greater life expectancy than life-long aspirin alone. The cost-effectiveness of adding clopidogrel—$15 400 per quality-adjusted life-year—is similar to that of many well-accepted interventions.
Ann Intern Med. 2005;142(4):251-259. doi:10.7326/0003-4819-142-4-200502150-00007
Niteesh K. Choudhry, MD; Robert H. Fletcher, MD, MSc; Stephen B. Soumerai, ScD
The authors systematically reviewed studies relating medical knowledge and health care quality to years in practice and physician age. Seventy-three percent of the evaluations showed decreasing performance with increasing years in practice for all or some of the outcomes assessed. Four percent of evaluations showed improving performance with increasing experience. Physicians who have been in practice longer may be at risk for providing lower-quality care.
Ann Intern Med. 2005;142(4):260-273. doi:10.7326/0003-4819-142-4-200502150-00008
Armin Alaedini, PhD; Peter H.R. Green, MD
This review discusses current concepts in the clinical presentation and diagnosis of celiac disease. It describes the pathogenesis of the disease; the diagnostic usefulness of serologic markers, including the sensitivity and specificity of available tests; and the association of celiac disease with other disorders.
Ann Intern Med. 2005;142(4):289-298. doi:10.7326/0003-4819-142-4-200502150-00011
Martin J. Tobin, MD
This year's Update in Pulmonary Diseases incorporates articles on mechanical ventilation, obstructive lung disease, and pulmonary infection.
Ann Intern Med. 2005;142(4):283-288. doi:10.7326/0003-4819-142-4-200502150-00010
Sharon K. Inouye, MD, MPH; David A. Fiellin, MD
This article provides recommendations on how to write a grant for clinical research. It describes specific problems that grant reviewers frequently identify in their critiques and shows how to avoid these problems.
Ann Intern Med. 2005;142(4):274-282. doi:10.7326/0003-4819-142-4-200502150-00009
Jonathan M. Samet, MD, MS
The new results from the Lung Health Study, reported in this issue, confirm again that smoking cessation prolongs life. In addition to their public health importance, these findings remind clinicians that interventions do increase the rate of successful quitting. The implications are obvious: Physicians should obtain a smoking history from all patients, and they should help smokers quit.
Ann Intern Med. 2005;142(4):299-301. doi:10.7326/0003-4819-142-4-200502150-00012
Steven E. Weinberger, MD; F. Daniel Duffy, MD; Christine K. Cassel, MD
The medical profession cannot ignore the striking findings reported by Choudhry and colleagues and their implications: Practice does not make perfect. Physicians must make an ongoing vigorous effort to maintain their knowledge and skills, and they must work actively to sustain the quality of care in their practice.
Ann Intern Med. 2005;142(4):302-303. doi:10.7326/0003-4819-142-4-200502150-00014
Sara Sasha Battar, MD
Dean, 87, and his wife Donna, 78, would ritualistically arrive every 3 months in my geriatrics clinic, rain or shine. They had been married for 61 years. From the beginning, Donna ably presumed the spokesperson's role and impressed me as a reliable and caring informant who knew Dean more than he knew himself.
Ann Intern Med. 2005;142(4):304. doi:10.7326/0003-4819-142-4-200502150-00015
Ann Intern Med. 2005;142(4):305. doi:10.7326/0003-4819-142-4-200502150-00016
Ann Intern Med. 2005;142(4):305-307. doi:10.7326/0003-4819-142-4-200502150-00017
Ann Intern Med. 2005;142(4):307-308. doi:10.7326/0003-4819-142-4-200502150-00018
Ann Intern Med. 2005;142(4):308. doi:10.7326/0003-4819-142-4-200502150-00019
Ann Intern Med. 2005;142(4):308-309. doi:10.7326/0003-4819-142-4-200502150-00020
Ann Intern Med. 2005;142(4):309. doi:10.7326/0003-4819-142-4-200502150-00021
Ann Intern Med. 2005;142(4):309-310. doi:10.7326/0003-4819-142-4-200502150-00022
Ann Intern Med. 2005;142(4):310. doi:10.7326/0003-4819-142-4-200502150-00023
Ann Intern Med. 2005;142(4):310-311. doi:10.7326/0003-4819-142-4-200502150-00024
Ann Intern Med. 2005;142(4):311. doi:10.7326/0003-4819-142-4-200502150-00025
Jerald Winakur, MD
Ann Intern Med. 2005;142(4):301. doi:10.7326/0003-4819-142-4-200502150-00013
Ann Intern Med. 2005;142(4):I-12. doi:10.7326/0003-4819-142-4-200502150-00001
Ann Intern Med. 2005;142(4):I-30. doi:10.7326/0003-4819-142-4-200502150-00002
Ann Intern Med. 2005;142(4):I-53. doi:10.7326/0003-4819-142-4-200502150-00003
Ann Intern Med. 2005;142(4):I-54. doi:10.7326/0003-4819-142-4-200502150-00004
David Hsia, JD, MD, MPH
Ann Intern Med. 2005;142(4):312. doi:10.7326/0003-4819-142-4-200502150-00026
David L. Freeman, MD
Ann Intern Med. 2005;142(4):312. doi:10.7326/0003-4819-142-4-200502150-00027
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