Alexander C. Tsai, MD, PhD; Michel Lucas, PhD, RD; Ayesha Sania, PhD; Daniel Kim, MD, DrPH; Ichiro Kawachi, MD, PhD
Suicide is increasing in incidence, especially among middle-aged men. Individual-level studies have lacked sufficient statistical power to investigate suicide in general population samples. In this study, the authors used data from the Health Professionals Follow-up Study to estimate the association between social integration and suicide over 24 years of follow-up. They found a more than 2-fold reduced risk for suicide among men who were socially well-integrated.
Ann Intern Med. 2014;161(2):85-95. doi:10.7326/M13-1291
Aaron S. Kesselheim, MD, JD, MPH; Katsiaryna Bykov, PharmD, MS; Jerry Avorn, MD; Angela Tong, MS; Michael Doherty, MS; Niteesh K. Choudhry, MD, PhD
Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these products may interrupt medication use. This cohort and nested case–control study found that variation in the appearance of generic drug pills is associated with lapses in use of essential drugs among patients with cardiovascular disease after myocardial infarction.
Ann Intern Med. 2014;161(2):96-103. doi:10.7326/M13-2381
Iris Lansdorp-Vogelaar, PhD; Roman Gulati, MS; Angela B. Mariotto, PhD; Clyde B. Schechter, MD, MA; Tiago M. de Carvalho, MSc; Amy B. Knudsen, PhD; Nicolien T. van Ravesteyn, PhD; Eveline A.M. Heijnsdijk, PhD; Chester Pabiniak, MSc; Marjolein van Ballegooijen, MD, PhD; Carolyn M. Rutter, PhD; Karen M. Kuntz, ScD; Eric J. Feuer, PhD; Ruth Etzioni, PhD; Harry J. de Koning, MD, PhD; Ann G. Zauber, PhD; Jeanne S. Mandelblatt, MD, MPH
The net benefit of cancer screening depends on the patient's age and comorbid conditions, but reliable methods of evaluating when to cease screening are lacking. This modeling study estimated the harms and benefits of screening with mammography, prostate-specific antigen, and fecal immunochemical testing at various ages and comorbid conditions and demonstrates how the presence and severity of comorbid conditions might be included in decisions about cancer screening.
Ann Intern Med. 2014;161(2):104-112. doi:10.7326/M13-2867
Ryan J. Shaw, PhD, RN; Jennifer R. McDuffie, PhD; Cristina C. Hendrix, DNS, NP; Alison Edie, DNP, FNP; Linda Lindsey-Davis, PhD, RN; Avishek Nagi, MS; Andrzej S. Kosinski, PhD; John W. Williams Jr., MD, MHSc
The Patient Protection and Affordable Care Act has resulted in more access to medical care for patients with chronic disease. Nurse-managed protocols for outpatient management of patients with chronic conditions may help meet the increased demand for care. This systematic review identified and evaluated 18 studies and concluded that these protocols can have a positive effect on the outpatient management of adults with chronic conditions.
Ann Intern Med. 2014;161(2):113-121. doi:10.7326/M13-2567
Rachael L. Fleurence, PhD; Laura P. Forsythe, PhD, MPH; Michael Lauer, MD; Jason Rotter, MHS; John P.A. Ioannidis, DSc, MD; Anne Beal, MD, MPH; Lori Frank, PhD; Joseph V. Selby, MD, MPH
The Patient-Centered Outcomes Research Institute conducted a merit review in November 2012 that included patients, other stakeholders, and scientists. The authors examined the differences between and relationships among the scores given to research applications by each reviewer group. Patient and stakeholder perspectives and scores differed significantly from those of scientists, but in-person discussion led to closer agreement among reviewers.
Ann Intern Med. 2014;161(2):122-130. doi:10.7326/M13-2412
Laura Faden Garabedian, PhD; Paula Chu, MS; Sengwee Toh, ScD; Alan M. Zaslavsky, PhD; Stephen B. Soumerai, ScD
Instrumental variable analysis is an increasingly popular method in comparative effectiveness research, but results of such analyses may be biased if the instrument and outcome are related through an unadjusted third variable (an “instrument–outcome confounder”). The authors examined 187 studies that used instrumental variable analysis and concluded that many effect estimates may have been biased by failure to adjust for instrument–outcome confounding.
Ann Intern Med. 2014;161(2):131-138. doi:10.7326/M13-1887
Aaron J. Calderon, MD; James S. Newman, MD; Neil H. Winawer, MD
This Update summarizes studies published in 2013 that the authors consider highly relevant to the practice of hospital medicine. Topics include Clostridium difficile infection; issues in the intensive care unit; inpatient management of diabetes, chronic obstructive pulmonary disease exacerbations, and heart failure; and venous thromboembolism prophylaxis in hip replacement.
Ann Intern Med. 2014;161(2):139-144. doi:10.7326/M14-0266
Julia Shaklee Sammons, MD, MSCE
Measles incidence in the United States is increasing due to vaccination refusal and disease importation. Yet, many currently practicing clinicians have never seen a case. It is crucial that clinicians become familiar with this potentially fatal disease and apply measures necessary to contain it.
Ann Intern Med. 2014;161(2):145-146. doi:10.7326/M14-0892
Ronald O. Valdiserri, MD, MPH; Howard K. Koh, MD, MPH
Viral hepatitis is a major public health problem in the United States. In this commentary, officials from the U.S. Department of Health and Human Services address current challenges and opportunities for the control of viral hepatitis and comment on the updated version of the Viral Hepatitis Action Plan for 2014–2016.
Ann Intern Med. 2014;161(2):147-148. doi:10.7326/M14-0404
Benjamin R. Roman, MD; David A. Asch, MD, MBA
This commentary discusses the difficulty in ceasing practices that physicians have come to believe in despite evidence showing that those practices have little value. The authors suggest several approaches to lessen patient dissatisfaction when attempting to discontinue entrenched low-value practices.
Ann Intern Med. 2014;161(2):149-150. doi:10.7326/M14-0212
Kerry Knox, PhD, MS
In this issue, Tsai and colleagues present the results of a longitudinal cohort study of men that examined the relationship of social integration and suicide. The editorialist discusses the study and the recent U.S. Preventive Services Task Force recommendation statement on suicide screening and stresses the importance of a public health approach to suicide prevention.
Ann Intern Med. 2014;161(2):151-152. doi:10.7326/M14-0914
Sandeep Jauhar, MD, PhD; David Battinelli, MD
In this issue, Shaw and colleagues describe how nurse-managed protocols can have a positive effect on the outpatient management of adults with chronic conditions. The editorialists discuss the study and its findings, as well as causes of the shortage of primary care physicians despite an increasing need for their services.
Ann Intern Med. 2014;161(2):153-154. doi:10.7326/M14-1308
Katherine C. Chretien, MD
It was midday on a spring Wednesday, my pager was on, and I had to be back at the hospital later to check in with my resident team. Now I was on a mission to find a funeral home.
Ann Intern Med. 2014;161(2):155-156. doi:10.7326/M14-0086
Ann Intern Med. 2014;161(2):157. doi:10.7326/L14-5014
Ann Intern Med. 2014;161(2):157-158. doi:10.7326/L14-5014-2
Ann Intern Med. 2014;161(2):158-159. doi:10.7326/L14-5014-3
Ann Intern Med. 2014;161(2):159. doi:10.7326/L14-5014-4
Jack Coulehan, MD, MPH
Ann Intern Med. 2014;161(2):160. doi:10.7326/M14-0149
Ann Intern Med. 2014;161(2):JC2. doi:10.7326/0003-4819-161-2-201407150-02002
Ann Intern Med. 2014;161(2):JC3. doi:10.7326/0003-4819-161-2-201407150-02003
Ann Intern Med. 2014;161(2):JC4. doi:10.7326/0003-4819-161-2-201407150-02004
Ann Intern Med. 2014;161(2):JC5. doi:10.7326/0003-4819-161-2-201407150-02005
Ann Intern Med. 2014;161(2):JC6. doi:10.7326/0003-4819-161-2-201407150-02006
Ann Intern Med. 2014;161(2):JC7. doi:10.7326/0003-4819-161-2-201407150-02007
Ann Intern Med. 2014;161(2):JC8. doi:10.7326/0003-4819-161-2-201407150-02008
Ann Intern Med. 2014;161(2):JC9. doi:10.7326/0003-4819-161-2-201407150-02009
Ann Intern Med. 2014;161(2):JC10. doi:10.7326/0003-4819-161-2-201407150-02010
Ann Intern Med. 2014;161(2):JC11. doi:10.7326/0003-4819-161-2-201407150-02011
Ann Intern Med. 2014;161(2):JC12. doi:10.7326/0003-4819-161-2-201407150-02012
Ann Intern Med. 2014;161(2):JC13. doi:10.7326/0003-4819-161-2-201407150-02013
Geno J. Merli, MD; Howard H. Weitz, MD
The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.
Ann Intern Med. 2014;161(2):CG7. doi:10.7326/G14-3007
Ann Intern Med. 2014;161(2):I-15. doi:10.7326/P14-9022
Ann Intern Med. 2014;161(2):I-22. doi:10.7326/P14-9023
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