Barbara Ellen Jones, MD, MSc; Brian Sauer, PhD; Makoto M. Jones, MD, MSc; Jose Campo, MD; Kavitha Damal, PhD, CCRC; Tao He, MS; Jian Ying, PhD, MStat; Tom Greene, PhD; Matthew Bidwell Goetz, MD; Melinda M. Neuhauser, PharmD, MPH; Lauri A. Hicks, DO; Matthew H. Samore, MD
Prescribing antibiotics for acute respiratory infections contributes to overall overuse. In this cross-sectional study, the authors examined the trends in antibiotic prescribing for acute respiratory infections in veterans and identified patient, provider, and setting sources of variation. They found that veterans with acute respiratory infections often received antibiotics, regardless of patient, provider, or setting.
Ann Intern Med. 2015;163(2):73-80. doi:10.7326/M14-1933
Allison M. Liddell, MD; Richard T. Davey Jr., MD; Aneesh K. Mehta, MD; Jay B. Varkey, MD; Colleen S. Kraft, MD, MSc; Gebre K. Tseggay, MD; Oghenetega Badidi, MD; Andrew C. Faust, PharmD; Katia V. Brown, MD; Anthony F. Suffredini, MD; Kevin Barrett, RN; Mark J. Wolcott, PhD; Vincent C. Marconi, MD; G. Marshall Lyon III, MD, MMSc; Gary L. Weinstein, MD; Kenney Weinmeister, MD; Shelby Sutton, MD; Munir Hazbun, MD; César G. Albariño, PhD; Zachary Reed, MPH; Debi Cannon; Ute Ströher, PhD; Mark Feldman, MD; Bruce S. Ribner, MD, MPH; H. Clifford Lane, MD; Anthony S. Fauci, MD; Timothy M. Uyeki, MD, MPH, MPP
Detailed clinical data are limited on the clinical course and management of patients with Ebola virus disease (EVD) outside western Africa. In this retrospective clinical case series, the authors describe the clinical characteristics and management of a cluster of patients with EVD, including the first cases of infection acquired in the United States.
Ann Intern Med. 2015;163(2):81-90. doi:10.7326/M15-0530
Philip J. Molloy, MD; Sam R. Telford III, ScD; Hanumara Ram Chowdri, MD; Timothy J. Lepore, MD; Joseph L. Gugliotta, MD; Karen E. Weeks, BS; Mary Ellen Hewins, BS; Heidi K. Goethert, ScD; Victor P. Berardi
The first recognized cases of Borrelia miyamotoi disease (BMD) in North America were reported in the northeastern United States in 2013. In this case series, the authors examined clinical features of acutely febrile patients with suspected tick-transmitted infections to further describe the clinical spectrum and laboratory findings for BMD. Their findings suggest that BMD should be part of the differential diagnosis of febrile patients from areas where deer tick–transmitted infections are endemic.
Ann Intern Med. 2015;163(2):91-98. doi:10.7326/M15-0333
Madina Agénor, ScD, MPH; Sarah Peitzmeier, MSPH; Allegra R. Gordon, MPH; Sebastien Haneuse, PhD; Jennifer E. Potter, MD; S. Bryn Austin, ScD
This survey examined the association between sexual orientation identity and human papillomavirus (HPV) vaccination among U.S. women and girls. The authors found that adolescent and young adult lesbians may be less likely to initiate HPV vaccination than their heterosexual counterparts.
Ann Intern Med. 2015;163(2):99-106. doi:10.7326/M14-2108
Howard A. Fink, MD, MPH; Laura S. Hemmy, PhD; Roderick MacDonald, MS; Maureen H. Carlyle, MPH; Carin M. Olson, MD, MS; Maurice W. Dysken, MD; J. Riley McCarten, MD; Robert L. Kane, MD; Santiago A. Garcia, MD; Indulis R. Rutks, BS; Jeannine Ouellette; Timothy J. Wilt, MD, MPH
This systematic review summarized the evidence about cognitive outcomes in adults aged 65 years or older at least 3 months after cardiovascular procedures. The authors found that intermediate- and long-term cognitive impairment in older adults attributable to the studied cardiovascular procedures may be uncommon.
Ann Intern Med. 2015;163(2):107-117. doi:10.7326/M14-2793
Frederick A. Spencer, MD; Manya Prasad, MBBS; Per O. Vandvik, MD, PhD; Devin Chetan, HBA; Qi Zhou, PhD; Gordon Guyatt, MD
This systematic review of longer- versus shorter-duration dual-antiplatelet therapy (DAPT) in patients receiving drug-eluting stents found that extended DAPT was associated with fewer myocardial infarctions but more major bleeding events than shorter-duration DAPT.
Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083
Hajime Uno, PhD; Janet Wittes, PhD; Haoda Fu, PhD; Scott D. Solomon, MD; Brian Claggett, PhD; Lu Tian, ScD; Tianxi Cai, ScD; Marc A. Pfeffer, MD, PhD; Scott R. Evans, PhD; Lee-Jen Wei, PhD
Noninferiority studies are often used to investigate whether a treatment's efficacy or safety profile is acceptable compared with another therapy. When time to a clinical event is of interest, treatment difference is routinely quantified using the hazard ratio (HR). The HR may be difficult to interpret, especially when the proportional hazards assumption is violated, and its precision does not depend directly on exposure times or sample size. This article provides alternative strategies that offer more meaningful interpretations of results.
Ann Intern Med. 2015;163(2):127-134. doi:10.7326/M14-1741
Hilary Daniel, BS; Renee Butkus, BA; for the Health and Public Policy Committee of the American College of Physicians
This position paper from the American College of Physicians (ACP) offers recommendations on how to reduce health disparities for lesbian, gay, bisexual, and transgender (LGBT) persons in the health care system.
Ann Intern Med. 2015;163(2):135-137. doi:10.7326/M14-2482
Robert B. Doherty, BA
On 16 April 2015, President Obama signed the Medicare Access and Children's Health Insurance Program Reauthorization Act, or MACRA. In addition to repealing the sustainable growth rate formula, this act promises to transform Medicare physician payments from a system that rewards volume to one that recognizes value. This commentary discusses how MACRA offers physicians more stability and potentially more control over reimbursement.
Ann Intern Med. 2015;163(2):138-139. doi:10.7326/M15-0992
Jennifer Potter, MD
Health disparities in the LGBT community are the topic of this issue's discussion from the Annals archive.
Ann Intern Med. 2015;163(2):140. doi:10.7326/M15-1298
Peter J. Krause, MD; Alan G. Barbour, MD
In this issue, Molloy and colleagues report the first large case series of Borrelia miyamotoi infection in the United States. The editorialists discuss the epidemiology and clinical presentation of the illness, as well as treatment options that can alleviate symptoms and prevent complications.
Ann Intern Med. 2015;163(2):141-142. doi:10.7326/M15-1219
Jeanne M. Marrazzo, MD, MPH
In this issue, the ACP makes recommendations on addressing the health disparities in the LGBT community and Agènor and colleagues report on the underuse of the HPV vaccine in lesbian women. The editorialist discusses these important articles and argues that it is time that the medical profession mobilizes to ensure that the health needs of LGBT persons are met.
Ann Intern Med. 2015;163(2):143-144. doi:10.7326/M15-0329
Richard Allen, MD, MPH
The contrasts of old age can be stark: once competent, now totally dependent; once a servant, now in constant need. Once he trusted Western medicine to diagnose and cure, now he was skeptical as we urged them to give up.
Ann Intern Med. 2015;163(2):145-146. doi:10.7326/M15-0023
Ann Intern Med. 2015;163(2):147. doi:10.7326/L15-5109
Ann Intern Med. 2015;163(2):147-148. doi:10.7326/L15-5109-2
Ann Intern Med. 2015;163(2):148. doi:10.7326/L15-5109-3
Ann Intern Med. 2015;163(2):148-149. doi:10.7326/L15-5110
Ann Intern Med. 2015;163(2):149. doi:10.7326/L15-5110-2
Ann Intern Med. 2015;163(2):149-150. doi:10.7326/L15-5111
Ann Intern Med. 2015;163(2):150-151. doi:10.7326/L15-5111-2
Ann Intern Med. 2015;163(2):151. doi:10.7326/L15-5112
Ann Intern Med. 2015;163(2):151. doi:10.7326/L15-5112-2
Ann Intern Med. 2015;163(2):151-152. doi:10.7326/L15-5113
Ann Intern Med. 2015;163(2):152. doi:10.7326/L15-5113-2
Ann Intern Med. 2015;163(2):JC2. doi:10.7326/ACPJC-2015-163-2-002
Ann Intern Med. 2015;163(2):JC3. doi:10.7326/ACPJC-2015-163-2-003
Ann Intern Med. 2015;163(2):JC4. doi:10.7326/ACPJC-2015-163-2-004
Ann Intern Med. 2015;163(2):JC5. doi:10.7326/ACPJC-2015-163-2-005
Ann Intern Med. 2015;163(2):JC6. doi:10.7326/ACPJC-2015-163-2-006
Ann Intern Med. 2015;163(2):JC7. doi:10.7326/ACPJC-2015-163-2-007
Ann Intern Med. 2015;163(2):JC8. doi:10.7326/ACPJC-2015-163-2-008
Ann Intern Med. 2015;163(2):JC9. doi:10.7326/ACPJC-2015-163-2-009
Ann Intern Med. 2015;163(2):JC10. doi:10.7326/ACPJC-2015-163-2-010
Ann Intern Med. 2015;163(2):JC11. doi:10.7326/ACPJC-2015-163-2-011
Ann Intern Med. 2015;163(2):JC12. doi:10.7326/ACPJC-2015-163-2-012
Ann Intern Med. 2015;163(2):JC13. doi:10.7326/ACPJC-2015-163-2-013
Geno J. Merli, MD; Howard H. Weitz, MD
The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.
Ann Intern Med. 2015;163(2):CG1. doi:10.7326/G15-3007
Ann Intern Med. 2015;163(2):I-24. doi:10.7326/P15-9008
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