Yoosoo Chang, MD, PhD; Seungho Ryu, MD, PhD; Yuni Choi, BS; Yiyi Zhang, PhD; Juhee Cho, PhD; Min-Jung Kwon, MD, PhD; Young Youl Hyun, MD, PhD; Kyu-Beck Lee, MD, PhD; Hyang Kim, MD, PhD; Hyun-Suk Jung, MD; Kyung Eun Yun, MD, PhD; Jiin Ahn, MSPH; Sanjay Rampal, MD, PhD; Di Zhao, PhD; Byung-Seong Suh, MD, PhD; Eun Cheol Chung, MD, PhD; Hocheol Shin, MD, PhD; Roberto Pastor-Barriuso, PhD; Eliseo Guallar, MD, DrPH
The risk for chronic kidney disease (CKD) among patients who are obese but do not have metabolic abnormalities is unknown. This cohort study of South Korean men and women compared the risk for incident CKD among metabolically healthy underweight, normal-weight, overweight, and obese participants.
Ann Intern Med. 2016;164(5):305-312. doi:10.7326/M15-1323
Lindsey R. Baden, MD; Etienne Karita, MD; Gaudensia Mutua, MBChB; Linda-Gail Bekker, MD; Glenda Gray, MBBCh; Liesl Page-Shipp, MD; Stephen R. Walsh, MD; Julien Nyombayire, MD; Omu Anzala, MBChB, PhD; Surita Roux, MD; Fatima Laher, MBBCh; Craig Innes, MD; Michael S. Seaman, PhD; Yehuda Z. Cohen, MD; Lauren Peter; Nicole Frahm, PhD; M. Juliana McElrath, MD, PhD; Peter Hayes, PhD; Edith Swann, PhD; Nicole Grunenberg, MD; Maria Grazia-Pau, MSc; Mo Weijtens, PhD; Jerry Sadoff, MD; Len Dally, MSc; Angela Lombardo, PhD; Jill Gilmour, PhD; Josephine Cox, PhD; Raphael Dolin, MD; Patricia Fast, MD, PhD; Dan H. Barouch, MD, PhD; Dagna S. Laufer, MD; for the B003-IPCAVD004-HVTN091 Study Group
New antiviral regimens have reduced mortality due to HIV infection, but an effective prophylactic vaccine is needed to control this global pandemic. Two HIV-1 preventive vaccines were tested in this international randomized, controlled trial. The vaccines elicited both humoral and cellular immune responses in all populations regardless of baseline vector immunity.
Ann Intern Med. 2016;164(5):313-322. doi:10.7326/M15-0880
Tobias Freund, MD; Frank Peters-Klimm, MD; Cynthia M. Boyd, MD; Cornelia Mahler, MA; Jochen Gensichen, MD; Antje Erler, MD; Martin Beyer, MA; Matthias Gondan, PhD; Justine Rochon, MSc; Ferdinand M. Gerlach, MD; Joachim Szecsenyi, MD
Some observers believe that medical assistants in office practice are an underutilized resource. This study examined outpatients with multiple chronic conditions who were likely to be hospitalized and whether they would have fewer hospitalizations and better quality of life when medical assistants monitored their care.
Ann Intern Med. 2016;164(5):323-330. doi:10.7326/M14-2403
Gerald Gartlehner, MD, MPH; Bradley N. Gaynes, MD, MPH; Halle R. Amick, MSPH; Gary N. Asher, MD, MPH; Laura C. Morgan, MA; Emmanuel Coker-Schwimmer, MPH; Catherine Forneris, PhD, ABPP; Erin Boland, BA; Linda J. Lux, PhD; Susan Gaylord, PhD; Carla Bann, PhD; Christiane Barbara Pierl, PhD, MPH; Kathleen N. Lohr, PhD, MPhil, MA
This meta-analysis of 45 randomized trials addresses the comparative benefits and harms of the following interventions for major depression: second-generation antidepressants, cognitive behavioral therapy, complementary and alternative medicine treatments, and exercise.
Ann Intern Med. 2016;164(5):331-341. doi:10.7326/M15-1813
Valerie Forman-Hoffman, PhD, MPH; Emily McClure, MSPH; Joni McKeeman, PhD; Charles T. Wood, MD; Jennifer Cook Middleton, PhD; Asheley C. Skinner, PhD; Eliana M. Perrin, MD, MPH; Meera Viswanathan, PhD
This systematic review for the U.S. Preventive Services Task Force addresses screening for and treatment of major depressive disorder in children and adolescents.
Ann Intern Med. 2016;164(5):342-349. doi:10.7326/M15-2259
Amir Qaseem, MD, PhD, MHA; Michael J. Barry, MD; Devan Kansagara, MD, MCR; for the Clinical Guidelines Committee of the American College of Physicians
This American College of Physicians guideline provides clinical recommendations for treating major depressive disorder in adults with second-generation antidepressant or nonpharmacologic treatments, such as psychotherapy, complementary and alternative medicine, and exercise.
Ann Intern Med. 2016;164(5):350-359. doi:10.7326/M15-2570
Albert L. Siu, MD, MSPH; on behalf of the U.S. Preventive Services Task Force
In this guideline on screening for major depressive disorder in children and adolescents, the U.S. Preventive Services Task Force summarizes evidence on the accuracy of primary care–feasible screening tests and on the benefits and harms of treatment with psychotherapy, medications, and collaborative care models.
Ann Intern Med. 2016;164(5):360-366. doi:10.7326/M15-2957
Mosoka Fallah, PhD, MPH; Bernice Dahn, MD, MPH; Tolbert G. Nyenswah, Esq, MPH; Moses Massaquoi, MD, MPH; Laura A. Skrip, MPH; Dan Yamin, PhD; Martial Ndeffo Mbah, PhD; Netty Joe, MD; Siedoh Freeman, MD; Thomas Harris, BA; Zinnah Benson, BBA; Alison P. Galvani, PhD
In Liberia, programs based on community engagement were effective in controlling the Ebola virus disease epidemic. This article details the community-based initiative that was instrumental to the shift in transmission dynamics.
Ann Intern Med. 2016;164(5):367-369. doi:10.7326/M15-1464
Christine A. Sinsky, MD
In this issue, Freund and colleagues report a trial of a modest intervention powered by medical assistants to keep patients out of the hospital. The editorialist notes that we do well with care of acute conditions and rescue care, to which the health care system devotes considerable resources. To equally master chronic illness care will require similar resources and careful coordination of appropriately trained personnel.
Ann Intern Med. 2016;164(5):370-371. doi:10.7326/M16-0008
John W. Williams Jr., MD, MHSc; Gary Maslow, MD, MPH
This issue includes guidelines from the U.S. Preventive Services Task Force on screening for depression in children and adolescents and from the American College of Physicians on treating adults with depression as well as their background reviews. The editorialists discuss the articles and why they believe that current times offer opportunities to improve the care of individuals with depression.
Ann Intern Med. 2016;164(5):372-373. doi:10.7326/M16-0104
Ann Intern Med. 2016;164(5):374. doi:10.7326/L15-0614
Ann Intern Med. 2016;164(5):374-375. doi:10.7326/L15-0615
Ann Intern Med. 2016;164(5):375-376. doi:10.7326/L15-0633
Ann Intern Med. 2016;164(5):376. doi:10.7326/L15-0632
Ann Intern Med. 2016;164(5):376. doi:10.7326/L16-0022
Stephen T. Harvey, MD
Ann Intern Med. 2016;164(5):341. doi:10.7326/M15-2103
Manish S. Patel, MD; Michael B. Steinberg, MD, MPH
Ann Intern Med. 2016;164(5):ITC33-ITC48. doi:10.7326/AITC201603010
Darren B. Taichman, MD, PhD
Ann Intern Med. 2016;164(5):ED5. doi:10.7326/AFED201603010
Catherine H.Y. Yu, MD; Julie H.Y. Man, MSc
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics##mdash;whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2016;164(5):GM1. doi:10.7326/G15-0015
Ann Intern Med. 2016;164(5):I-28. doi:10.7326/P16-9006
Ann Intern Med. 2016;164(5):I-18. doi:10.7326/P16-9010
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