Kenneth Cusi, MD; Beverly Orsak, RN; Fernando Bril, MD; Romina Lomonaco, MD; Joan Hecht, RN; Carolina Ortiz-Lopez, MD; Fermin Tio, MD; Jean Hardies, PhD; Celia Darland, RD; Nicolas Musi, MD; Amy Webb, MD; Paola Portillo-Sanchez, MD
Nonalcoholic steatohepatitis (NASH) is a common chronic liver condition affecting obese patients with prediabetes or type 2 diabetes mellitus (T2DM). Pioglitazone seems to target metabolic defects, such as insulin resistance and adipose tissue dysfunction, that are associated with both NASH and T2DM. This trial examined the efficacy and safety of pioglitazone treatment of NASH in patients with prediabetes or T2DM.
Ann Intern Med. 2016;165(5):305-315. doi:10.7326/M15-1774
Gustaf Edgren, MD, PhD; Henrik Hjalgrim, MD, PhD, DrMedSci; Klaus Rostgaard, MSc; Paul Lambert, PhD; Agneta Wikman, MD, PhD; Rut Norda, MD, PhD; Kjell-Einar Titlestad, MD, PhD; Christian Erikstrup, MD, PhD; Henrik Ullum, MD, PhD; Mads Melbye, MD, DrMedSci; Michael P. Busch, MD, PhD; Olof Nyrén, MD, PhD
Similarities with prion diseases and findings in animal models raise concern that certain neurodegenerative disorders, including Alzheimer and Parkinson diseases, might be transmissible through transfusion of blood products. This study used Scandinavian national databases to assess the risk for neurodegenerative diseases among recipients of blood products from donors who were diagnosed with such conditions.
Ann Intern Med. 2016;165(5):316-324. doi:10.7326/M15-2421
Rochelle P. Walensky, MD, MPH; Ethan D. Borre, BA; Linda-Gail Bekker, MD, PhD; Stephen C. Resch, PhD; Emily P. Hyle, MD, SM; Robin Wood, MMed, DSc (Med); Milton C. Weinstein, PhD; Andrea L. Ciaranello, MD, MPH; Kenneth A. Freedberg, MD, MSc; A. David Paltiel, MBA, PhD
UNAIDS (The Joint United Nations Programme on HIV/AIDS) has set an ambitious goal of diagnosing 90% of HIV-infected persons worldwide, linking 90% of those diagnosed to effective therapy, and achieving virologic suppression in 90% of treated persons. In this study, a microsimulation model estimated the health and social value of such a program in South Africa.
Ann Intern Med. 2016;165(5):325-333. doi:10.7326/M16-0799
Giuseppe Gargiulo, MD; Anna Sannino, MD; Davide Capodanno, MD, PhD; Marco Barbanti, MD; Sergio Buccheri, MD; Cinzia Perrino, MD, PhD; Piera Capranzano, MD; Ciro Indolfi, MD, PhD; Bruno Trimarco, MD; Corrado Tamburino, MD, PhD; Giovanni Esposito, MD, PhD
This meta-analysis compares the benefits and harms of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) for adults with severe aortic stenosis and found that TAVI may have similar or better early and midterm clinical outcomes than SAVR in these patients, including those at low to intermediate risk.
Ann Intern Med. 2016;165(5):334-344. doi:10.7326/M16-0060
J. Morgan Freiman, MD; Trang M. Tran, BA; Samuel G. Schumacher, MSc, PhD; Laura F. White, PhD; Stefano Ongarello, PhD; Jennifer Cohn, MD, MPH; Philippa J. Easterbrook, MD, MPH; Benjamin P. Linas, MD, MPH; Claudia M. Denkinger, MD, PhD
Diagnosis of chronic hepatitis C virus (HCV) infection usually requires both a positive HCV antibody screen and confirmatory nucleic acid testing (NAT). This systematic review of 44 studies evaluates 5 commercially available hepatitis C core antigen tests as alternatives to NAT.
Ann Intern Med. 2016;165(5):345-355. doi:10.7326/M16-0065
Karen E. Hauer, MD, PhD; Jerome Clauser, EdD; Rebecca S. Lipner, PhD; Eric S. Holmboe, MD; Kelly Caverzagie, MD; Stanley J. Hamstra, PhD; Sarah Hood, MS; William Iobst, MD; Eric Warm, MD; Furman S. McDonald, MD, MPH
Internal medicine residency training programs recently began evaluating residents' achievement of the milestones deemed necessary for completion of training. This study assessed the initial evaluations of all U.S. internal medicine residents submitted by program directors in the first year that reporting was required.
Ann Intern Med. 2016;165(5):356-362. doi:10.7326/M15-2411
Dalia Deak, MPH; Kevin Outterson, LLM, JD; John H. Powers, MD; Aaron S. Kesselheim, MD, JD, MPH
Because of the rising incidence of drug-resistant pathogens, legislation has been enacted to accelerate rapid development of new antibiotics. Using publicly available data, the authors examined the development process for antibiotics approved from 2010 to 2015 and assessed evidence of innovation as well as cost and effect on patient outcomes.
Ann Intern Med. 2016;165(5):363-372. doi:10.7326/M16-0291
Eduardo Vilar-Gomez, MD, PhD; Leon A. Adams, MBBS, PhD
Cusi and colleagues' randomized trial evaluated pioglitazone for the treatment of patients with NASH and T2DM. The editorialists discuss the findings and believe that pharmacologic therapies, such as pioglitazone, are welcome additions to the therapeutic armamentarium for NASH.
Ann Intern Med. 2016;165(5):373-374. doi:10.7326/M16-1303
Ann Intern Med. 2016;165(5):375. doi:10.7326/L16-0103
Ann Intern Med. 2016;165(5):375-376. doi:10.7326/L16-0104
Ann Intern Med. 2016;165(5):376-377. doi:10.7326/L16-0168
Ann Intern Med. 2016;165(5):376. doi:10.7326/L16-0169
Ann Intern Med. 2016;165(5):377-378. doi:10.7326/L16-0110
Ann Intern Med. 2016;165(5):378. doi:10.7326/L16-0111
Ann Intern Med. 2016;165(5):378-379. doi:10.7326/L16-0109
Ann Intern Med. 2016;165(5):379-380. doi:10.7326/L16-0107
Ann Intern Med. 2016;165(5):379. doi:10.7326/L16-0108
Arthur Kim, MD
Ann Intern Med. 2016;165(5):ITC33-ITC48. doi:10.7326/AITC201609060
Ann Intern Med. 2016;165(5):JITC33-JITC48. doi:10.7326/IsTranslatedFrom_AITC201609060_Japanese
Darren B. Taichman, MD, PhD
Ann Intern Med. 2016;165(5):ED5. doi:10.7326/AFED201609060
Sharon Rosenzweig, BFA, MFA
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2016;165(5):W6-W11. doi:10.7326/G16-0010
Ann Intern Med. 2016;165(5):I-15. doi:10.7326/P16-9018
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