Colleen R. Kelly, MD; Alexander Khoruts, MD; Christopher Staley, PhD; Michael J. Sadowsky, PhD; Mortadha Abd, MD; Mustafa Alani, MD; Brianna Bakow, BA; Patrizia Curran, MD; Joyce McKenney, MS; Allison Tisch, NP; Steven E. Reinert, MS; Jason T. Machan, PhD; Lawrence J. Brandt, MD
Evidence for the efficacy and safety of fecal microbiota transplantation (FMT) in recurrent Clostridium difficile infection (CDI) is limited. In this randomized trial conducted at 2 academic medical centers, the authors evaluated the efficacy and safety of colonoscopic FMT among patients who had 3 or more recurrences of CDI and received a full course of vancomycin for their most recent acute episode.
Ann Intern Med. 2016;165(9):609-616. doi:10.7326/M16-0271
Mark Loeb, MD; Margaret L. Russell, MD, PhD; Vanessa Manning, BSc; Kevin Fonseca, PhD; David J.D. Earn, PhD; Gregory Horsman, MD; Khami Chokani, MD; Mark Vooght, MD; Lorne Babiuk, PhD; Lisa Schwartz, PhD; Binod Neupane, PhD; Pardeep Singh, BSc; Stephen D. Walter, PhD; Eleanor Pullenayegum, PhD
It has been postulated that by providing both herd and direct protection, intranasal live attenuated influenza vaccine (LAIV) may be more effective than inactivated influenza vaccine (IIV) at the community level. This cluster randomized blinded trial comparing the efficacy of LAIV with IIV in preventing laboratory-confirmed influenza was done in children living in rural Hutterite colonies.
Ann Intern Med. 2016;165(9):617-624. doi:10.7326/M16-0513
Gregory J. Dore, MD; Frederick Altice, MD; Alain H. Litwin, MD; Olav Dalgard, MD; Edward J. Gane, MD; Oren Shibolet, MD; Anne Luetkemeyer, MD; Ronald Nahass, MD; Cheng-Yuan Peng, MD; Brian Conway, MD; Jason Grebely, PhD; Anita Y.M. Howe, PhD; Isaias N. Gendrano, MPH; Erluo Chen, MPH; Hsueh-Cheng Huang, PhD; Frank J. Dutko, PhD; David C. Nickle, PhD; Bach-Yen Nguyen, MD; Janice Wahl, MD; Eliav Barr, MD; Michael N. Robertson, MD; Heather L. Platt, MD; on behalf of the C-EDGE CO-STAR Study Group
Hepatitis C virus (HCV) infection is common in persons who inject drugs (PWID), a population that generally has been excluded from trials of HCV treatment. This study randomly assigned treatment-naive PWID with chronic HCV genotype 1, 4, or 6 infection who were receiving opioid agonist therapy to immediate or delayed treatment with elbasvir–grazoprevir to evaluate its effectiveness and safety for this population.
Ann Intern Med. 2016;165(9):625-634. doi:10.7326/M16-0816
Gowri Raman, MD, MS; Gaelen P. Adam, MLIS; Christopher W. Halladay, BA, ScM; Valerie N. Langberg, ScM; Ijeoma A. Azodo, MD, ChM; Ethan M. Balk, MD, MPH
This systematic review of 83 studies compares benefits and harms of percutaneous transluminal renal angioplasty with stent placement versus medical therapy alone in adults with atherosclerotic renal artery stenosis.
Ann Intern Med. 2016;165(9):635-649. doi:10.7326/M16-1053
Dae Hyun Kim, MD, MPH, ScD; Caroline A. Kim, MD, MS, MPH; Sebastian Placide, BA; Lewis A. Lipsitz, MD; Edward R. Marcantonio, MD, ScM
This systematic review examines evidence regarding the ability of various frailty instruments to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events in older adults undergoing cardiac surgical procedures.
Ann Intern Med. 2016;165(9):650-660. doi:10.7326/M16-0652
Nadia A. Khan, MD, MSc
Findings from recent randomized trials indicate benefit from even lower systolic blood pressure targets than previously recommended for antihypertensive treatment. The author argues that duplicating these benefits in clinical practice will require validated means of identifying the appropriate patients, not just the provision of antihypertensive therapies.
Ann Intern Med. 2016;165(9):661-662. doi:10.7326/M16-1421
Frank A. Lederle, MD; William C. Cushman, MD; Ryan E. Ferguson, ScD, MPH; Mary T. Brophy, MD, MPH; Louis D. Fiore, MD, MPH
This article is an overview of a large, multicenter, randomized clinical trial that will compare the effects of hydrochlorothiazide with chlorthalidone on cardiovascular events among Veterans Affairs patients.
Ann Intern Med. 2016;165(9):663-664. doi:10.7326/M16-1208
Olivia A. Wackowski, PhD, MPH; Cristine D. Delnevo, PhD, MPH; Michael B. Steinberg, MD, MPH
Recent statements by the U.S. Food and Drug Administration and the Royal College of Physicians differ in their approach to available data about electronic cigarettes. The authors discuss what may be taken from each approach and provide advice to clinicians seeking to counsel patients.
Ann Intern Med. 2016;165(9):665-666. doi:10.7326/M16-1345
Elizabeth L. Hohmann, MD
Kelly and colleagues report a randomized trial of fecal microbiota transplantation versus autologous stool for recurrent Clostridium difficile infection. The editorialist discusses possible explanations for the site differences in cure rates among patients receiving autologous stool.
Ann Intern Med. 2016;165(9):667-668. doi:10.7326/M16-1784
Victoria L. Tang, MD, MAS; Kenneth Covinsky, MD, MPH
Kim and colleagues present a systematic review on preoperative frailty assessment and long-term outcomes in older adults undergoing cardiac surgical procedures. The editorialists discuss how the findings support assessing older adults considering surgery for frailty. Through identifying frailty, we may be able to improve care for our older surgical patients.
Ann Intern Med. 2016;165(9):669-670. doi:10.7326/M16-1866
Renuka Gupta, MD
I knew where this was going. It was not the first time a patient had asked me about my training. Some patients are just curious. Others are trying to get at something deeper, more insidious.
Ann Intern Med. 2016;165(9):671-672. doi:10.7326/M15-2370
Ann Intern Med. 2016;165(9):673-674. doi:10.7326/L16-0283
Ann Intern Med. 2016;165(9):674. doi:10.7326/L16-0284
Ann Intern Med. 2016;165(9):673. doi:10.7326/L16-0400
Ann Intern Med. 2016;165(9):674-675. doi:10.7326/L16-0332
Ann Intern Med. 2016;165(9):675. doi:10.7326/L16-0330
Ann Intern Med. 2016;165(9):675. doi:10.7326/L16-0331
Ann Intern Med. 2016;165(9):675-676. doi:10.7326/L16-0333
Ann Intern Med. 2016;165(9):676-677. doi:10.7326/L16-0410
Ann Intern Med. 2016;165(9):677. doi:10.7326/L16-0409
Ann Intern Med. 2016;165(9):677-678. doi:10.7326/L16-0002
Ann Intern Med. 2016;165(9):678-679. doi:10.7326/L16-0023
Ann Intern Med. 2016;165(9):679. doi:10.7326/L16-0532
Terri Kirby Erickson, BA
Ann Intern Med. 2016;165(9):672. doi:10.7326/M16-1839
Laura Michelle Sherwood, BS, BA
Ann Intern Med. 2016;165(9):680. doi:10.7326/M16-1401
Gary S. Hoffman, MD, MS
Ann Intern Med. 2016;165(9):ITC65-ITC80. doi:10.7326/AITC201611010
Darren B. Taichman, MD, PhD
Ann Intern Med. 2016;165(9):ED9. doi:10.7326/AFED201611010
Lucia Briatore, MD, PhD; Ilaria Pozzi
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2016;165(9):W13-W14. doi:10.7326/G16-0017
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