Julie C. Lauffenburger, PharmD, PhD; William H. Shrank, MD, MSHS; Asaf Bitton, MD, MPH; Jessica M. Franklin, PhD; Robert J. Glynn, PhD; Alexis A. Krumme, MS; Olga S. Matlin, PhD; Edmund J. Pezalla, MD, MPH; Claire M. Spettell, PhD; Gregory Brill, MS; Niteesh K. Choudhry, MD, PhD
Poor medication adherence is viewed as a key measure of quality of care by major organizations. However, it has not been evaluated in primary care practices that meet recognition criteria for patient-centered medical homes (PCMHs). In this cohort study, the authors assess the association between medication adherence and PCMHs in a national patient and provider population.
Ann Intern Med. 2017;166(2):81-88. doi:10.7326/M15-2659
Kirsten K. Ness, PhD; Melissa M. Hudson, MD; Kendra E. Jones, MS; Wendy Leisenring, ScD; Yutaka Yasui, PhD; Yan Chen, MS; Marilyn Stovall, PhD; Todd M. Gibson, PhD; Daniel M. Green, MD; Joseph P. Neglia, MD; Tara O. Henderson, MD; Jacqueline Casillas, MD; Jennifer S. Ford, PhD; Karen E. Effinger, MD, MS; Kevin R. Krull, PhD; Gregory T. Armstrong, MD, MSCE; Leslie L. Robison, PhD; Kevin C. Oeffinger, MD; Paul C. Nathan, MD
Death due to childhood cancer has decreased markedly in the United States. In this large multicenter survey, selfreport of health status by adult survivors of childhood cancer was evaluated as a function of treatment decade, cancer treatment exposures, chronic health conditions, demographics, and health habits.
Ann Intern Med. 2017;166(2):89-98. doi:10.7326/M16-0742
Davidson H. Hamer, MD; Kira A. Barbre, MPH; Lin H. Chen, MD; Martin P. Grobusch, MD, PhD; Patricia Schlagenhauf, PhD; Abraham Goorhuis, MD, PhD; Perry J.J. van Genderen, MD, PhD; Israel Molina, MD, PhD; Hilmir Asgeirsson, MD, PhD; Phyllis E. Kozarsky, MD; Eric Caumes, MD; Stefan H. Hagmann, MD, MSc; Frank P. Mockenhaupt, MD; Gilles Eperon, MD; Elizabeth D. Barnett, MD; Emmanuel Bottieau, MD, PhD; Andrea K. Boggild, MSc, MD; Philippe Gautret, MD, PhD; Noreen A. Hynes, MD, MPH; Susan Kuhn, MD; R. Ryan Lash, MA; Karin Leder, MBBS, MPH, PhD; Michael Libman, MD; Denis J.M. Malvy, MD, PhD; Cecilia Perret, MD; Camilla Rothe, MD; Eli Schwartz, MD; Annelies Wilder-Smith, MD, PhD, MIH; Martin S. Cetron, MD; Douglas H. Esposito, MD, MPH; for the GeoSentinel Surveillance Network
Using data from the GeoSentinel Surveillance Network, the authors describe the clinical manifestations and epidemiology of Zika virus disease in travelers exposed in South America, Central America, and the Caribbean through February 2016. Their findings emphasize the need for careful pretravel advice for persons planning travel to countries with ongoing Zika virus transmission.
Ann Intern Med. 2017;166(2):99-108. doi:10.7326/M16-1842
Massimo Colombo, MD; Alessio Aghemo, MD; Hong Liu, PhD; Jie Zhang, PhD; Hadas Dvory-Sobol, PhD; Robert Hyland, DPhil; Chohee Yun, MD; Benedetta Massetto, MD; Diana M. Brainard, MD; John G. McHutchison, MD; Marc Bourlière, MD; Markus Peck-Radosavljevic, MD; Michael Manns, MD; Stanislas Pol, MD
In a multicenter, open-label clinical trial, kidney transplant recipients with chronic genotype 1 or 4 HCV infection were randomly assigned to receive ledipasvir–sofosbuvir for either 12 or 24 weeks. Outcomes included sustained viral suppression 12 weeks after the end of treatment, as well as safety and tolerability.
Ann Intern Med. 2017;166(2):109-117. doi:10.7326/M16-1205
Marc Arbyn, MD, MSc, DrTMH; Lan Xu, MSc; Freija Verdoodt, PhD; Jack Cuzick, PhD; Anne Szarewski, MD, PhD; Jerome L. Belinson, MD; Nicolas Wentzensen, MD, PhD; Julia C. Gage, PhD, MPH; Michelle J. Khan, MD, MPH
This meta-analysis addresses the accuracy of genotyping for HPV 16 and 18 as well as the utility of using such genotyping to triage women with minor cervical lesions for further diagnostic work-up.
Ann Intern Med. 2017;166(2):118-127. doi:10.7326/M15-2735
Yaolong Chen, PhD, MMed; Kehu Yang, MMed; Ana Marušić, MD, PhD; Amir Qaseem, MD, PhD, MHA; Joerg J. Meerpohl, MD; Signe Flottorp, MD, PhD; Elie A. Akl, MD, MPH, PhD; Holger J. Schünemann, MD, PhD; Edwin S.Y. Chan, PhD; Yngve Falck-Ytter, MD; Faruque Ahmed, PhD; Sarah Barber, PhD; Chiehfeng Chen, MD, MPH, PhD; Mingming Zhang, MSc; Bin Xu, MD; Jinhui Tian, PhD; Fujian Song, PhD; Hongcai Shang, MD, PhD; Kun Tang, PhD; Qi Wang, MMed; Susan L. Norris, MD, MPH, MSc; for the RIGHT (Reporting Items for Practice Guidelines in Healthcare) Working Group
No widely accepted guidance for reporting practice guidelines is available. This 22-item checklist and comprehensive explanatory document, developed by an international multidisciplinary team, details items considered essential for good reporting of practice guidelines.
Ann Intern Med. 2017;166(2):128-132. doi:10.7326/M16-1565
Michael Bretthauer, MD, PhD; Michal F. Kaminski, MD, PhD; Cesare Hassan, MD; Mette Kalager, MD, PhD; Øyvind Holme, MD, PhD; Geir Hoff, MD, PhD; Magnus Løberg, MD, PhD; Jaroslaw Regula, MD, PhD; Antoni Castells, MD, PhD; Hans-Olov Adami, MD, PhD
The authors discuss concerns about the updated recommendations for colorectal cancer screening from the USPSTF. They advocate for integration of high-quality clinical trials into ongoing screening programs to generate high-quality evidence for effectiveness of new screening strategies.
Ann Intern Med. 2017;166(2):139-140. doi:10.7326/M16-1805
Frank Davidoff, MD
Randomized clinical trials help identify the potential health benefits and harms of an intervention. But patients vary widely in their responses, and such heterogeneity makes it difficult for physicians and patients to choose whether to use a specific treatment. The author discusses the dangers of ignoring this problem and recent efforts to address it.
Ann Intern Med. 2017;166(2):141-142. doi:10.7326/M16-1721
Michael Dansinger, MD
In this commentary, a researcher whose work was plagiarized outlines the harm that intellectual theft causes both the plagiarist and those whose work has been stolen.
Ann Intern Med. 2017;166(2):143. doi:10.7326/M16-2551
Robert Doherty, BA
Many expect the newly consolidated Republican government to follow through on campaign promises to repeal and replace the Affordable Care Act. What kind of viable replacement will be proposed, how such talk will disrupt the insurance industry, and whether the 20 million newly insured Americans will be able to retain their coverage remain to be seen.
Ann Intern Med. 2017;166(2):144-145. doi:10.7326/M16-2728
Scott H. Podolsky, MD
This article discusses the effect of antibiotics on many aspects of human growth and health, which has garnered intense interest for more than 60 years.
Ann Intern Med. 2017;166(2):133-138. doi:10.7326/M16-1855
Michele Heisler, MD, MPA
Lauffenburger and colleagues report an assessment of adherence in PCMHs compared with a national sample of commercially insured adults initiating therapy with diabetes, blood pressure, or cholesterol medications. The editorialist discusses how this study adds to what we know about the relationship between PCMHs and medication adherence.
Ann Intern Med. 2017;166(2):146-147. doi:10.7326/M16-2397
Christine Laine, MD, MPH
Recently, Annals of Internal Medicine experienced an egregious case of scientific misconduct that this editorial brings to light for 2 reasons: to assure readers that Annals takes such matters very seriously and to serve as an example that might deter this behavior.
Ann Intern Med. 2017;166(2):148-149. doi:10.7326/M16-2550
Iris Ma, MD
Ann Intern Med. 2017;166(2):150-151. doi:10.7326/M16-0519
Ann Intern Med. 2017;166(2):152. doi:10.7326/L16-0528
Ann Intern Med. 2017;166(2):152-153. doi:10.7326/L16-0529
Ann Intern Med. 2017;166(2):153-155. doi:10.7326/L16-0122
Ann Intern Med. 2017;166(2):155-156. doi:10.7326/L16-0138
Michael Yelland, MBBS, PhD
Ann Intern Med. 2017;166(2):JC2. doi:10.7326/ACPJC-2017-166-2-002
Diego J. Maselli, MD; Jay I. Peters, MD
Ann Intern Med. 2017;166(2):JC3. doi:10.7326/ACPJC-2017-166-2-003
Warren G. Thompson, MD
Ann Intern Med. 2017;166(2):JC4. doi:10.7326/ACPJC-2017-166-2-004
Henry S. Sacks, PhD, MD
Ann Intern Med. 2017;166(2):JC5. doi:10.7326/ACPJC-2017-166-2-005
David Garcia, MD
Ann Intern Med. 2017;166(2):JC6. doi:10.7326/ACPJC-2017-166-2-006
James Brophy, MD, FRCP, FACC, PhD
Ann Intern Med. 2017;166(2):JC7. doi:10.7326/ACPJC-2017-166-2-007
Anthony A. Donato, MD, MHPE
Ann Intern Med. 2017;166(2):JC8. doi:10.7326/ACPJC-2017-166-2-008
Catherine M. Clase, MD
Ann Intern Med. 2017;166(2):JC9. doi:10.7326/ACPJC-2017-166-2-009
Bram Rochwerg, MD, MSc; Gordon Guyatt, MD, MSc
Ann Intern Med. 2017;166(2):JC10. doi:10.7326/ACPJC-2017-166-2-010
Mitchell Levine, MD
Ann Intern Med. 2017;166(2):JC11. doi:10.7326/ACPJC-2017-166-2-011
Geno J. Merli, MD; Howard H. Weitz, MD
Annals Consult Guys brings a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.
Ann Intern Med. 2017;166(2):CG1. doi:10.7326/W17-0001
Darren B. Taichman, MD, PhD
Ann Intern Med. 2017;166(2):ED2. doi:10.7326/AFED201701170
David H. Wesorick, MD; Vineet Chopra, MD, MSc
Ann Intern Med. 2017;166(2):HO1. doi:10.7326/AFHO201701170
Poonam Hosamani, MD; Abraham Verghese, MD
Ann Intern Med. 2017;166(2):HO2. doi:10.7326/M16-2737
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