Abraham J. Kandathil, PhD; Florian P. Breitwieser, PhD; Jaiprasath Sachithanandham, PhD; Matthew Robinson, MD; Shruti H. Mehta, PhD; Winston Timp, PhD; Steven L. Salzberg, PhD; David L. Thomas, MD, MPH; Ashwin Balagopal, MD
In this study, the authors used next-generation metagenomic sequencing to explore the plasma virome of injection drug users and characterized its sensitivity and accuracy compared with quantitative clinical standards. The findings included presence of a novel RNA virus (human hepegivirus-1) in several participants.
Ann Intern Med. 2017;167(1):1-7. doi:10.7326/M17-0085
Nick Bansback, PhD; Ciaran S. Phibbs, PhD; Huiying Sun, PhD; James R. O'Dell, MD; Mary Brophy, MD, MPH; Edward C. Keystone, MD; Sarah Leatherman, PhD; Ted R. Mikuls, MD, MSPH; Aslam H. Anis, PhD; for the CSP 551 RACAT Investigators
Bansback and colleagues used data from a recently published randomized controlled trial to examine the cost-effectiveness of triple therapy versus adding etanercept to methotrexate as a first-line strategy in patients with rheumatoid arthritis not controlled by methotrexate monotherapy.
Ann Intern Med. 2017;167(1):8-16. doi:10.7326/M16-0713
Raffaele Piccolo, MD; Giuseppe Gargiulo, MD; Anna Franzone, MD; Andrea Santucci, MD; Sara Ariotti, MD; Andrea Baldo, MD; Carlo Tumscitz, MD; Aris Moschovitis, MD; Stephan Windecker, MD; Marco Valgimigli, MD, PhD
In this study, the authors apply the dual-antiplatelet therapy (DAPT) score to a study that enrolled patients randomly assigned to a prolonged (24 months) versus short (≤6 months) DAPT regimen after percutaneous coronary intervention.
Ann Intern Med. 2017;167(1):17-25. doi:10.7326/M16-2389
Ajay Malhotra, MD, MMM; Xiao Wu, BS; Howard P. Forman, MD, MBA; Holly K. Grossetta Nardini, MLS; Charles C. Matouk, MD; Dheeraj Gandhi, MD; Christopher Moore, MD; Pina Sanelli, MD, MPH
Small intracranial aneurysms are sometimes detected incidentally on brain imaging. This systematic review of 26 observational studies assesses and summarizes evidence about the growth and rupture risk of small and very small intracranial aneurysms.
Ann Intern Med. 2017;167(1):26-33. doi:10.7326/M17-0246
Aïda Bafeta, PhD; Amelie Yavchitz, MD, PhD; Carolina Riveros, MSc; Rui Batista, PharmD; Philippe Ravaud, MD, PhD
Fecal microbiota transplantation is a novel treatment option for some chronic diseases with altered gut microbiota. This analysis of 85 published reports examines studies in humans that assessed the efficacy or safety of fecal microbiota transplantation.
Ann Intern Med. 2017;167(1):34-39. doi:10.7326/M16-2810
Isabelle Boutron, MD, PhD; Douglas G. Altman, DSc; David Moher, PhD; Kenneth F. Schulz, PhD, MBA; Philippe Ravaud, MD, PhD; for the CONSORT NPT Group
This article describes updates to the CONSORT extension on methodological issues specific to trials of nonpharmacologic treatments and an extension for reporting abstracts of trials of nonpharmacologic treatments.
Ann Intern Med. 2017;167(1):40-47. doi:10.7326/M17-0046
Samyukta Mullangi, MD, MBA; Andrew M. Ibrahim, MD, MSc; Vineet Chopra, MD, MSc
Hospitals are still behind when it comes to implementing patient-friendly processes to improve the access and layout of hospital services. Could hospitals learn from airports in meeting the needs of patients?
Ann Intern Med. 2017;167(1):48-49. doi:10.7326/M17-0484
A. Thomas McLellan, PhD
The Department of Veterans Affairs/Department of Defense recently revised guidelines on prescribing opioids for the management of chronic noncancer pain. This commentary discusses the guidelines and why they are a welcome and timely update.
Ann Intern Med. 2017;167(1):50-51. doi:10.7326/M17-0814
David Shulkin, MD
The newly appointed secretary of the U.S. Department of Veterans Affairs (VA) describes the response to the access crisis and his vision for the VA that is based on how veterans want to receive care.
Ann Intern Med. 2017;167(1):52-54. doi:10.7326/M17-0900
Elena Losina, PhD; Jeffrey N. Katz, MD, MSc
Bansback and colleagues reported a cost-effectiveness analysis of triple therapy with conventional disease-modifying antirheumatic drugs compared with etanercept and methotrexate. The editorialists discuss the findings.
Ann Intern Med. 2017;167(1):55-56. doi:10.7326/M17-1176
J. Dawn Abbott, MD
The editorialist discusses the findings of Piccolo and colleagues' study as well as strategies to individualize decision making about DAPT duration.
Ann Intern Med. 2017;167(1):57-58. doi:10.7326/M17-1211
Robert M. Starke, MD, MSc
Malhotra and colleagues' review examined the risk for growth and rupture of small unruptured intracranial aneurysms. The editorialist discusses the importance of the clinical question the review attempts to answer but believes that the poor quality of the available evidence makes the answer elusive.
Ann Intern Med. 2017;167(1):59-60. doi:10.7326/M17-1215
Vincent B. Young, MD, PhD
The editorialist discusses Bafeta and colleagues' systematic review, which examined the methods described in 85 studies of fecal microbiota transplantation.
Ann Intern Med. 2017;167(1):61-62. doi:10.7326/M17-1157
Darren B. Taichman, MD, PhD; Peush Sahni, MBBS, MS, PhD; Anja Pinborg, MD; Larry Peiperl, MD; Christine Laine, MD, MPH; Astrid James, MBBS; Sung-Tae Hong, MD, PhD; Abraham Haileamlak, MD; Laragh Gollogly, MD, MPH; Fiona Godlee, FRCP; Frank A. Frizelle, MBChB, FRACS; Fernando Florenzano, MD; Jeffrey M. Drazen, MD; Howard Bauchner, MD; Christopher Baethge, MD; Joyce Backus, MSLS
Participants in clinical trials often place themselves at risk to help the medical community learn how to improve care. To make the most of these efforts, the editors of 13 major medical journals have adopted new criteria on sharing data from clinical trials.
Ann Intern Med. 2017;167(1):63-65. doi:10.7326/M17-1028
Darren B. Taichman, MD, PhD; Darilyn V. Moyer, MD; Christine Laine, MD, MPH
This issue includes 2 Annals Graphic Medicine pieces about the beginning of internship. This editorial discusses what residents face during this time.
Ann Intern Med. 2017;167(1):66-67. doi:10.7326/M17-1293
Franklin J. Canady, BA
Ann Intern Med. 2017;167(1):68-69. doi:10.7326/M16-2226
Ann Intern Med. 2017;167(1):70-71. doi:10.7326/L16-0651
Ann Intern Med. 2017;167(1):71-72. doi:10.7326/L17-0189
Ann Intern Med. 2017;167(1):72-73. doi:10.7326/L17-0188
Ann Intern Med. 2017;167(1):72. doi:10.7326/L17-0192
Ann Intern Med. 2017;167(1):73-74. doi:10.7326/L17-0231
Ann Intern Med. 2017;167(1):74-75. doi:10.7326/L17-0233
Ann Intern Med. 2017;167(1):75-76. doi:10.7326/L17-0234
Venetta Masson, RN, MA
Ann Intern Med. 2017;167(1):16. doi:10.7326/M17-0373
Brenda Butka, MD
Ann Intern Med. 2017;167(1):65. doi:10.7326/M17-0257
Stanley Cohen, MD
Ann Intern Med. 2017;167(1):76. doi:10.7326/M17-0409
Judith Feinberg, MD; Susana Keeshin, MD
Ann Intern Med. 2017;167(1):ITC1-ITC16. doi:10.7326/AITC201707040
Darren B. Taichman, MD, PhD
Ann Intern Med. 2017;167(1):ED1. doi:10.7326/AFED201707040
Michael Natter, MD
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2017;167(1):W1-W2. doi:10.7326/G17-0008
Jason Bitterman, MD
Ann Intern Med. 2017;167(1):W3-W6. doi:10.7326/G17-0001
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