Marc R. Larochelle, MD, MPH; Dana Bernson, MPH; Thomas Land, PhD; Thomas J. Stopka, PhD, MHS; Na Wang, MA; Ziming Xuan, ScD, SM; Sarah M. Bagley, MD, MSc; Jane M. Liebschutz, MD, MPH; Alexander Y. Walley, MD, MSc
Patients who survive an opioid overdose are at increased risk for subsequent nonfatal and fatal events. This study evaluated overdose survivors to determine whether use of medications for opioid use disorder was associated with reduced mortality.
Ann Intern Med. 2018;169(3):137-145. doi:10.7326/M17-3107
Jonathan L. Chang, MPH; Alexander C. Tsai, MD, PhD; Nicholas Musinguzi, MS; Jessica E. Haberer, MD, MS; Yap Boum, PhD; Conrad Muzoora, MMed; Mwebesa Bwana, MMed; Jeffrey N. Martin, MD, MPH; Peter W. Hunt, MD; David R. Bangsberg, MD, MPH; Mark J. Siedner, MD, MPH
Some studies have found an association between efavirenz use and neuropsychiatric adverse outcomes in patients with HIV infection, but data from sub-Saharan Africa, where the drug is still widely used, are limited. In a large prospective cohort study in Uganda, the authors examined depression and suicidal ideation in patients receiving efavirenz versus those receiving nevirapine.
Ann Intern Med. 2018;169(3):146-155. doi:10.7326/M17-2252
Elizabeth Selvin, PhD, MPH; Dan Wang, MS; Kunihiro Matsushita, MD, PhD; Morgan E. Grams, MD, PhD, MHS; Josef Coresh, MD, PhD, MHS
Current clinical guidelines require repeated testing (“2-sample testing”) to confirm an elevated fasting glucose or hemoglobin A1c level and reduce the possibility of a false-positive diagnosis of diabetes mellitus. In this study, the authors examined the prognostic performance of a single-sample confirmatory definition of undiagnosed diabetes in identifying persons who subsequently developed diabetes or related complications.
Ann Intern Med. 2018;169(3):156-164. doi:10.7326/M18-0091
Anastasia-Vasiliki Madenidou, MD, MSc; Paschalis Paschos, MD, MSc; Thomas Karagiannis, MD, MSc; Anastasia Katsoula, MD, MSc; Eleni Athanasiadou, MSc; Konstantinos Kitsios, MD, PhD; Eleni Bekiari, MD, PhD, MSc; David R. Matthews, MD, DPhil; Apostolos Tsapas, MD, PhD, MSc
This network meta-analysis of 39 randomized trials examines the comparative benefits and harms of 10 basal insulin analogue regimens for adults with type 2 diabetes.
Ann Intern Med. 2018;169(3):165-174. doi:10.7326/M18-0443
Gerald W. Smetana, MD; Jennifer Beach, MD; Lewis Lipsitz, MD; Howard Libman, MD
The optimum threshold above which to begin antihypertensive therapy as well as the optimum target blood pressure to achieve with medication are areas of controversy, especially in older adults. Two guidelines published in 2017 address this issue. In this Beyond the Guidelines, 2 experts debate application of these guidelines to the care of a 79-year-old man with hypertension.
Ann Intern Med. 2018;169(3):175-182. doi:10.7326/M18-1312
Sanket S. Dhruva, MD, MHS; Joseph S. Ross, MD, MHS; Wade L. Schulz, MD, PhD; Harlan M. Krumholz, MD, SM
Medical devices are required to have unique identifiers, which have the potential to provide data to improve patient safety. The authors discuss why this potential is not being realized and suggest ways to overcome the barriers.
Ann Intern Med. 2018;169(3):183-185. doi:10.7326/M18-0526
Boris Draznin, MD, PhD; David M. Nathan, MD; Mary T. Korytkowski, MD; Marie E. McDonnell, MD; Sherita Hill Golden, MD, MHS; Mark H. Schutta, MD; William T. Cefalu, MD
Expert clinicians counter some of the recommendations regarding hemoglobin A1c targets for type 2 diabetes that were proposed in a recent American College of Physicians guideline.
Ann Intern Med. 2018;169(3):186-187. doi:10.7326/M18-0939
Sarah E. Wakeman, MD; Keren Ladin, PhD, MSc; Tim Brennan, MD; Raymond T. Chung, MD
Should people with opioid use disorder who are being treated with opioid agonist therapy be deemed ineligible for organ transplant? This commentary proposes an answer.
Ann Intern Med. 2018;169(3):188-189. doi:10.7326/M18-1099
Nora D. Volkow, MD; Eric M. Wargo, PhD
In their article, Larochelle and colleagues provided convincing evidence of the benefits of methadone and buprenorphine in preventing opioid-related deaths in patients with a history of nonfatal opioid overdose. The editorialists discuss the findings and what they reveal about the challenges of overcoming barriers to broader use of medication-assisted treatment of opioid use disorder.
Ann Intern Med. 2018;169(3):190-192. doi:10.7326/M18-1397
K. M. Venkat Narayan, MD, MSc, MBA; Ram Jagannathan, PhD
Selvin and colleagues reported the prognostic capability of “single-sample” definitions of confirmed (elevated levels of both fasting glucose and hemoglobin A1c) and unconfirmed (elevated level of fasting glucose level or hemoglobin A1c) undiagnosed diabetes to identify future risk for diagnosed diabetes and its complications. The editorialists discuss the promise of these findings (if they are confirmed in other populations) to improve the timing and efficiency of diabetes diagnosis.
Ann Intern Med. 2018;169(3):193-194. doi:10.7326/M18-1477
Lyssa Weatherly, MD
That morning, I became more aware than ever of the limits of medicine.
Ann Intern Med. 2018;169(3):195. doi:10.7326/M18-0679
Ann Intern Med. 2018;169(3):197-198. doi:10.7326/L17-0634
Ann Intern Med. 2018;169(3):198-199. doi:10.7326/M17-3381
Ann Intern Med. 2018;169(3):199-200. doi:10.7326/L18-0236
Ann Intern Med. 2018;169(3):200-201. doi:10.7326/L18-0237
Ann Intern Med. 2018;169(3):201-202. doi:10.7326/L18-0164
Ann Intern Med. 2018;169(3):202. doi:10.7326/L18-0165
Ann Intern Med. 2018;169(3):203. doi:10.7326/L18-0238
Ann Intern Med. 2018;169(3):203. doi:10.7326/L18-0239
Ann Intern Med. 2018;169(3):203-204. doi:10.7326/L18-0240
Ann Intern Med. 2018;169(3):204. doi:10.7326/L18-0241
Ann Intern Med. 2018;169(3):204. doi:10.7326/L18-0377
Gaetan Sgro, MD
Ann Intern Med. 2018;169(3):196. doi:10.7326/M18-0355
Kenneth Schmader, MD
Ann Intern Med. 2018;169(3):ITC17-ITC32. doi:10.7326/AITC201808070
Darren B. Taichman, MD, PhD
Ann Intern Med. 2018;169(3):ED3. doi:10.7326/AFED201808070
Robert M. Centor, MD; Robert M. McLean, MD
In this episode of Annals On Call, Dr. Centor discusses targeting treatment for gout with Dr. Robert McLean, a rheumatologist and a co-author of the American College of Physicians clinical guidelines on the management of gout.
Ann Intern Med. 2018;169(3):OC1. doi:10.7326/A18-0001
Kimberly R. Myers, MA, PhD; Molly Osborne, MD, PhD; Charlotte A. Wu, MD; Zoe S. Schein, MA
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2018;169(3):W6-W12. doi:10.7326/G17-0017
Ann Intern Med. 2018;169(3):I-16. doi:10.7326/P18-0009
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