Ron Carico, PharmD, MPH; Xinhua Zhao, PhD; Carolyn T. Thorpe, PhD, MPH; Joshua M. Thorpe, PhD, MPH; Florentina E. Sileanu, MS; John P. Cashy, PhD; Jennifer A. Hale, BA; Maria K. Mor, PhD; Thomas R. Radomski, MD, MS; Leslie R.M. Hausmann, PhD; Julie M. Donohue, PhD; Katie J. Suda, PharmD, MS; Kevin Stroupe, PhD; Joseph T. Hanlon, PharmD, MS; Chester B. Good, MD, MPH; Michael J. Fine, MD, MSc; Walid F. Gellad, MD, MPH
Receipt of overlapping prescriptions for opioids and benzodiazepines has been associated with an increased risk for overdose. This cross-sectional study compared the proportion of veterans who had overlapping opioids and benzodiazepines among those who received prescriptions solely from VA, solely from Medicare Part D, or from both.
Ann Intern Med. 2018;169(9):593-601. doi:10.7326/M18-0852
Manuel Zorzi, MD, MSc; Cesare Hassan, MD; Giulia Capodaglio, MS; Elena Narne, MD; Anna Turrin, MS; Maddalena Baracco, MSc; Antonella Dal Cin, MSc; Annarita Fiore, MSc; Giancarla Martin, LPN; Alessandro Repici, MD; Douglas Rex, MD; Massimo Rugge, MD
We know from previous studies that fecal immunochemical screening is more effective at detecting cancer in the distal rather than the proximal colon. Zorzi and colleagues report how this test property changes during 6 rounds of repeated screening.
Ann Intern Med. 2018;169(9):602-609. doi:10.7326/M18-0855
William R. Zhang, BS; Timothy E. Craven, MSPH; Rakesh Malhotra, MD; Alfred K. Cheung, MD; Michel Chonchol, MD; Paul Drawz, MD; Mark J. Sarnak, MD, MS; Chirag R. Parikh, MD, PhD; Michael G. Shlipak, MD, MPH; Joachim H. Ix, MD, MAS; for the SPRINT Research Group
Intensive lowering of systolic blood pressure may be associated with kidney injury. This nested case–control study examined changes in 9 urinary biomarkers of kidney damage among persons with incident chronic kidney disease in the intensive (<120 mm Hg) versus standard (<140 mm Hg) treatment groups of SPRINT (Systolic Blood Pressure Intervention Trial).
Ann Intern Med. 2018;169(9):610-618. doi:10.7326/M18-1037
Rakhi P. Naik, MD, MHS; Kim Smith-Whitley, MD; Kathryn L. Hassell, MD; Nkeiruka I. Umeh, BA; Mariane de Montalembert, MD, PhD; Puneet Sahota, MD, PhD; Carlton Haywood Jr., PhD; Jean Jenkins, PhD, RN; Michele A. Lloyd-Puryear, MD, PhD; Clinton H. Joiner, MD, PhD; Vence L. Bonham, JD; Gregory J. Kato, MD
Is sickle cell trait a benign carrier state? This systematic review examines evidence regarding risks for 24 adverse clinical outcomes in children and adults with sickle cell trait.
Ann Intern Med. 2018;169(9):619-627. doi:10.7326/M18-1161
Gordon D. Schiff, MD; Stephen A. Martin, MD, EdM; David H. Eidelman, MD; Lynn A. Volk, MHS; Elise Ruan, BS; Christine Cassel, MD; William Galanter, MD; Mark Johnson, MD, MS; Annemarie Jutel, PhD; Kurt Kroenke, MD; Bruce L. Lambert, PhD; Joel Lexchin, MSc, MD; Sara Myers, BA; Alexa Miller, MA; Stuart Mushlin, MD; Lisa Sanders, MD; Aziz Sheikh, MD
Physicians must navigate a balance between under- and overdiagnosis, both of which may harm patients. The authors discuss core principles to help find this balance and foster a thoughtful, patient-centered, more conservative approach to diagnosis.
Ann Intern Med. 2018;169(9):643-645. doi:10.7326/M18-1468
Ilana Braun, MD; James Tulsky, MD
Despite medical marijuana's increasing use and acceptance, physician understanding of the risks and benefits of its use, guidance from medical associations, and accommodations for documentation in electronic health records are lacking. The authors discuss these gaps, why they exist, and what can be done to address them.
Ann Intern Med. 2018;169(9):646-647. doi:10.7326/M18-1883
Zachary Munn, PhD; Amir Qaseem, MD, PhD, MHA; for the American College of Physicians and the Joanna Briggs Institute
Evidence-based guidelines play a pivotal role in optimizing quality of care and improving clinical outcomes for patients. In recognition of this important role, the National Guideline Clearinghouse (NGC) was created in 1998. In July 2018, the NGC went dark because of the federal government's budgetary cuts. This commentary discusses the potential negative consequences of this action.
Ann Intern Med. 2018;169(9):648-649. doi:10.7326/M18-2216
Stephen A. Martin, MD, EdM; Lisa M. Chiodo, PhD; Jordon D. Bosse, MS, RN; Amanda Wilson, MD
This special article addresses current evidence and recommendations regarding buprenorphine care for opioid use disorder.
Ann Intern Med. 2018;169(9):628-635. doi:10.7326/M18-1652
Anjali B. Thakkar, MD, MBA; Sukumar P. Desai, MD
Jeremy Swan and William Ganz developed their eponymous pulmonary artery catheter in the 1970s, and its use came to define critical care medicine in the late 20th century. This article describes the natural life cycle of this catheter as new, less invasive technology arrived to replace it.
Ann Intern Med. 2018;169(9):636-642. doi:10.7326/M17-2145
Chyke A. Doubeni, MD, MPH; Theodore R. Levin, MD
Zorzi and colleagues reported on the yield from 6 rounds of biennial colorectal cancer screening with the fecal immunochemical test (FIT) from 2002 to 2015 in a fixed cohort. The editorialists discuss the study findings, the advantages of FIT, and the need for studies to examine whether screening with FIT prevents right colon cancer deaths.
Ann Intern Med. 2018;169(9):650-651. doi:10.7326/M18-2444
Kathryn Hawk, MD, MHS; Gail D'Onofrio, MD, MS
In their article, Martin and colleagues address buprenorphine treatment for opioid use disorder. The editorialists discuss the findings and why they believe that we need to disrupt current practice and change our approach to treatment of persons with opioid use disorder.
Ann Intern Med. 2018;169(9):652-653. doi:10.7326/M18-2722
Milda R. Saunders, MD, MPH; Barbara J. Turner, MD, MSEd
Read and colleagues' cross-sectional survey of internists showed that the salary gap between women and men in the medical profession has long been an unfortunate, unconscionable norm that persists in internal medicine. The editorialists discuss the findings and speculate about strategies that could promote gender equity in physician compensation.
Ann Intern Med. 2018;169(9):654-655. doi:10.7326/M18-1879
Peter Louis Loper Jr., MD
How might we be delivered from both this fast-food addiction and the addictions promoted by our health care system?
Ann Intern Med. 2018;169(9):656. doi:10.7326/M18-2250
Ann Intern Med. 2018;169(9):657-658. doi:10.7326/L18-0177
Ann Intern Med. 2018;169(9):658-661. doi:10.7326/M18-0693
Ann Intern Med. 2018;169(9):661. doi:10.7326/L18-0465
Ann Intern Med. 2018;169(9):661-662. doi:10.7326/L18-0466
Ann Intern Med. 2018;169(9):662. doi:10.7326/L18-0410
Ann Intern Med. 2018;169(9):662-663. doi:10.7326/L18-0411
Ann Intern Med. 2018;169(9):663. doi:10.7326/L18-0511
Ann Intern Med. 2018;169(9):663-664. doi:10.7326/L18-0512
Ann Intern Med. 2018;169(9):664. doi:10.7326/L18-0497
Xiao Jing Wang, MD; Harmeet Malhi, MD
Ann Intern Med. 2018;169(9):ITC65-ITC80. doi:10.7326/AITC201811060
Darren B. Taichman, MD, PhD
Ann Intern Med. 2018;169(9):ED9. doi:10.7326/AFED201811060
Robert M. Centor, MD; Rodney A. Hayward, MD
In this episode of Annals On Call, Dr. Centor discusses an update of the pooled cohort equations used to estimate atherosclerotic cardiovascular disease risk with Dr. Rodney Hayward. Dr. Hayward was a co-investigator on a recent study that updated the equations to improve prediction in sex and race subgroups.
Ann Intern Med. 2018;169(9):OC1. doi:10.7326/A18-0007
Emily Steinberg, MFA
This comic (yes, a comic!) visually captures the experience of a patient with menopausal symptoms.
Ann Intern Med. 2018;169(9):W33-W39. doi:10.7326/G18-0004
Ann Intern Med. 2018;169(9):I-20. doi:10.7326/P18-0015
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