Brian T. Bateman, MD, MSc; Uffe Heide-Jørgensen, MSc, PhD; Kristjana Einarsdóttir, PhD; Anders Engeland, MSc, PhD; Kari Furu, MScPharm, MPH, PhD; Mika Gissler, PhD; Sonia Hernandez-Diaz, MD, DrPH; Helle Kieler, MD, PhD; Anna-Maria Lahesmaa-Korpinen, PhD; Helen Mogun, MS; Mette Nørgaard, MD, PhD; Johan Reutfors, MD, PhD; Randi Selmer, MSc, PhD; Krista F. Huybrechts, MS, PhD; Helga Zoega, MA, PhD
β-Blockers are among the most commonly used antihypertensive medications during pregnancy, but concerns have been raised about their potential teratogenic effects. These authors analyzed data from nationwide health registries in 5 Nordic countries and the U.S. Medicaid population to examine the risk for congenital malformations in offspring of women with hypertension who were exposed to β-blockers during the first trimester of pregnancy.
Ann Intern Med. 2018;169(10):665-673. doi:10.7326/M18-0338
Maria Salgado, PhD; Mi Kwon, MD; Cristina Gálvez, MS; Jon Badiola, MD; Monique Nijhuis, PhD; Alessandra Bandera, MD, PhD; Pascual Balsalobre, PhD; Pilar Miralles, MD; Ismael Buño, PhD; Carolina Martinez-Laperche, PhD; Cristina Vilaplana, MD, PhD; Manuel Jurado, MD, PhD; Bonaventura Clotet, MD, PhD; Annemarie Wensing, MD; Javier Martinez-Picado, PhD; Jose Luis Diez-Martin, MD, PhD; for the IciStem Consortium
The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT) are not fully understood. In this nested case series within an observational cohort, the authors investigate the mechanism of HIV-1 eradication associated with allo-HSCT.
Ann Intern Med. 2018;169(10):674-683. doi:10.7326/M18-0759
Jihyoun Jeon, PhD; Theodore R. Holford, PhD; David T. Levy, PhD; Eric J. Feuer, PhD; Pianpian Cao, MPH; Jamie Tam, PhD; Lauren Clarke, MSc; John Clarke, MSc; Chung Yin Kong, PhD; Rafael Meza, PhD
Although lung cancer mortality has decreased since the 1990s, lung cancer remains the leading cause of cancer death in the United States. This study used 4 simulation models of the natural history of lung cancer to project the effect of existing tobacco control efforts on lung cancer and mortality rates from 2015 to 2065.
Ann Intern Med. 2018;169(10):684-693. doi:10.7326/M18-1250
Matthieu Roustit, PharmD, PhD; Joris Giai, MD, MSc; Olivier Gaget, MD; Charles Khouri, PharmD; Myriam Mouhib, PharmD; Adrien Lotito, PharmD; Sophie Blaise, MD, PhD; Christophe Seinturier, MD; Fabien Subtil, PhD; Adeline Paris, PharmD, PhD; Claire Cracowski, MD; Bernard Imbert, MD; Patrick Carpentier, MD, PhD; Sunita Vohra, MD, PhD; Jean-Luc Cracowski, MD, PhD
Raynaud phenomenon (RP) characteristically occurs during exposure to cold. Using a series of randomized, double-blind, n-of-1 trials, the authors assessed the efficacy and safety of on-demand sildenafil as an alternative to daily treatment for RP.
Ann Intern Med. 2018;169(10):694-703. doi:10.7326/M18-0517
Renee Butkus, BA; Robert Doherty, BA; Sue S. Bornstein, MD; for the Health and Public Policy Committee of the American College of Physicians
Firearm-related injuries continue to threaten public health in the United States. This position paper provides policy recommendations from the American College of Physicians that are aimed at reducing firearm-related morbidity and mortality.
Ann Intern Med. 2018;169(10):704-707. doi:10.7326/M18-1530
Y. Tony Yang, ScD, LLM, MPH; Stanton Glantz, PhD
In June 2018, voters in San Francisco supported implementation of a law prohibiting the sale of flavored tobacco products, including menthol cigarettes and flavored vaping liquids, despite a $12 million campaign funded almost entirely by the R.J. Reynolds Tobacco Company to oppose the law. This commentary discusses the vote and the public health campaign to support it.
Ann Intern Med. 2018;169(10):708-709. doi:10.7326/M18-2317
Steven A. Schroeder, MD
In response to mounting concern about the use of electronic cigarettes by young people, the commissioner of the U.S. Food and Drug Administration recently released an action plan together with a demand that manufacturers report how they will address the problem and a threat to accelerate regulations. The author discusses the potential consequences of such actions, as well as inaction, and the potential risks and benefits involved.
Ann Intern Med. 2018;169(10):710-711. doi:10.7326/M18-2738
Mark Levine, MD; Michael Fraser, PhD, MS
The Centers for Disease Control and Prevention's report of overdose deaths from prescription and illicit opioids underscores the need for urgent action to prevent overdose deaths, promote evidence-based programs for treatment and recovery, and implement programs and policies that support primary prevention of addiction. The authors discuss the report and its implications, as well as how no single public health tactic or policy will end the opioid crisis.
Ann Intern Med. 2018;169(10):712-715. doi:10.7326/M18-1757
Lilia M. Cortina, PhD; Reshma Jagsi, MD, DPhil
The medical profession is not immune from sexual harassment, and culture change is needed. The authors discuss taxonomies and findings from the social sciences that merit consideration by the medical profession as it strives to change culture to prevent sexual harassment.
Ann Intern Med. 2018;169(10):716-717. doi:10.7326/M18-2047
Joel G. Ray, MD, MSc
The editorialist discusses Bateman and colleaguesï¿½ findings and their clinical implications for caring for pregnant women who have hypertension or other conditions that require β-blockers.
Ann Intern Med. 2018;169(10):718. doi:10.7326/M18-2500
Richard D'Aquila, MD
How are latent HIV reservoirs so radically depleted by allo-HSCT? Salgado and colleagues report on the largest number of HIV-infected patients receiving allo-HSCT with CCR5 wild-type donor cells for hematologic disease who have been studied to date and begin to address this question. The editorialist discusses the implications of the findings.
Ann Intern Med. 2018;169(10):719-720. doi:10.7326/M18-2822
Gerard A. Silvestri, MD, MS; Matthew J. Carpenter, PhD
Jeon and colleagues reported computer models that project lung cancer mortality among U.S. adults. The editorialists discuss the important messages about smoking, screening, and lung cancer that these projections provide.
Ann Intern Med. 2018;169(10):721-722. doi:10.7326/M18-2775
Philip J. Cook, PhD
The editorialist discusses the American College of Physicians' position paper on reducing the public health crisis of firearm-related injury and how the focus and efforts of physicians and others should consider additional factors to help address the crisis.
Ann Intern Med. 2018;169(10):723-724. doi:10.7326/M18-2846
James S. Kahn, MD
This issue includes a position paper from the American College of Physicians on the health care crisis of firearm-related injury and a research study assessing perceptions of the problem among physicians and the public. The editorialist describes how and why he asks his patients about firearm safety.
Ann Intern Med. 2018;169(10):725-726. doi:10.7326/M18-2756
Douglas C. Throckmorton, MD; Janet Woodcock, MD
Gomes and colleagues explore the trends and consequences of the recent and striking increase in gabapentinoid prescribing, particularly in combination with opioids. The editorialists discuss these findings and the need to carefully investigate the consequences of combined use of all central nervous system–active drugs.
Ann Intern Med. 2018;169(10):727-728. doi:10.7326/M18-2175
Michelle M. Kittleson, MD, PhD
Loved ones may move through Elisabeth Kübler-Ross' stages of grief-from denial to anger to bargaining to sadness and, finally, to acceptance-but what is the trajectory of a doctor's grief?
Ann Intern Med. 2018;169(10):729-730. doi:10.7326/M18-2049
Ann Intern Med. 2018;169(10):732-734. doi:10.7326/M18-1136
Ann Intern Med. 2018;169(10):734-737. doi:10.7326/M18-1533
Ann Intern Med. 2018;169(10):737-738. doi:10.7326/L18-0463
Ann Intern Med. 2018;169(10):738. doi:10.7326/L18-0464
Ann Intern Med. 2018;169(10):738-739. doi:10.7326/L18-0513
Ann Intern Med. 2018;169(10):739. doi:10.7326/L18-0514
Ann Intern Med. 2018;169(10):739-740. doi:10.7326/L18-0522
Ann Intern Med. 2018;169(10):740. doi:10.7326/L18-0523
Ann Intern Med. 2018;169(10):740. doi:10.7326/L18-0570
Brian W. Christman, MD
Ann Intern Med. 2018;169(10):715. doi:10.7326/M18-0371
D.A. Frater, MD
Ann Intern Med. 2018;169(10):730. doi:10.7326/M18-0665
Eva M. Mathews, MD, MPH
Ann Intern Med. 2018;169(10):731. doi:10.7326/M18-1066
Ann Intern Med. 2018;169(10):JC50. doi:10.7326/ACPJC-2018-169-10-050
Ann Intern Med. 2018;169(10):JC51. doi:10.7326/ACPJC-2018-169-10-051
Ann Intern Med. 2018;169(10):JC52. doi:10.7326/ACPJC-2018-169-10-052
Ann Intern Med. 2018;169(10):JC53. doi:10.7326/ACPJC-2018-169-10-053
Ann Intern Med. 2018;169(10):JC54. doi:10.7326/ACPJC-2018-169-10-054
Ann Intern Med. 2018;169(10):JC55. doi:10.7326/ACPJC-2018-169-10-055
Ann Intern Med. 2018;169(10):JC56. doi:10.7326/ACPJC-2018-169-10-056
Ann Intern Med. 2018;169(10):JC57. doi:10.7326/ACPJC-2018-169-10-057
Ann Intern Med. 2018;169(10):JC58. doi:10.7326/ACPJC-2018-169-10-058
Ann Intern Med. 2018;169(10):JC59. doi:10.7326/ACPJC-2018-169-10-059
Geno J. Merli, MD; Howard H. Weitz, MD
>Annals Consult Guys brings a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2018;169(10):CG1. doi:10.7326/W18-0026
Darren B. Taichman, MD, PhD
Ann Intern Med. 2018;169(10):ED10. doi:10.7326/AFED201811200
David H. Wesorick, MD; Vineet Chopra, MD, MSc
Ann Intern Med. 2018;169(10):HO1. doi:10.7326/AFHO201811200
Paul J. Grant, MD
Perioperative management of patients receiving systemic anticoagulation for atrial fibrillation or flutter can be challenging. This commentary discusses why clinicians should reconsider the need to bridge most patients with low-molecular-weight heparin during temporary cessation of warfarin therapy.
Ann Intern Med. 2018;169(10):HO2-HO3. doi:10.7326/M18-2734
Robert M. Centor, MD; David A. Calhoun, MD
In this episode of Annals On Call, Dr. Centor discusses primary aldosteronism and hypertension with Dr. David Calhoun. Recent evidence suggest we may be missing the diagnosis more often than we think.
Ann Intern Med. 2018;169(10):OC1. doi:10.7326/A18-0008
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