Yves Lévy, MD, PhD; Jean-Daniel Lelièvre, MD, PhD; Lambert Assoumou, PhD; Esther Aznar, MD; Federico Pulido, PhD; Giuseppe Tambussi, MD; Manuel Crespo, PhD; Agnès Meybeck, MD; Jean-Michel Molina, MD, PhD; Constance Delaugerre, MD, PhD; Jacques Izopet, MD, PhD; Gilles Peytavin, PhD; Fanny Cardon, MSc; Alpha Diallo, MD, MPH; Rémi Lancar, PhD; Lydie Béniguel, PhD; Dominique Costagliola, PhD
This randomized trial evaluates whether there is a benefit of adding maraviroc, an antiretroviral drug with immunologic effects, to standard combined antiretroviral therapy for patients with advanced disease at HIV diagnosis.
Ann Intern Med. 2020;172(5):297-305. doi:10.7326/M19-2133
Ibrahim Aldoss, MD; Corinna La Rosa, PhD; Lindsey R. Baden, MD; Jeffrey Longmate, PhD; Ella J. Ariza-Heredia, MD; Wasima N. Rida, PhD; Chetan Raj Lingaraju, MS; Qiao Zhou, BS; Joy Martinez, MS; Teodora Kaltcheva, PhD; Andy Dagis, MS; Nicola Hardwick, PhD; Nicolas C. Issa, MD; Len Farol, MD; Auayporn Nademanee, MD; Monzr M. Al Malki, MD; Stephen Forman, MD; Ryotaro Nakamura, MD; Don J. Diamond, PhD; for the TRIPLEX VACCINE Study Group
Reactivation of latent cytomegalovirus (CMV) in CMV-seropositive recipients of allogeneic stem cell transplant (HCT) is associated with increased morbidity and mortality after HCT. There is an unmet need for a durable approach to suppressing both early and late CMV reactivation and its sequelae. The objective of this multicenter, double-blind, randomized, placebo-controlled, phase 2 trial was to evaluate the safety and efficacy of a poxvirus vectored CMV vaccine to prevent CMV viremia in recipients of HCT.
Ann Intern Med. 2020;172(5):306-316. doi:10.7326/M19-2511
Adela M. Greeley, MD; Elizabeth P. Tanner, MD; Selene Mak, PhD, MPH; Meron M. Begashaw, MPH; Isomi M. Miake-Lye, PhD; Paul G. Shekelle, MD, PhD
This systematic review examines 20 studies that evaluated whether adding sitters to usual care or using alternatives to sitters (such as video monitors or close observation units) reduced falls in adult patients on general wards of acute care hospitals.
Ann Intern Med. 2020;172(5):317-324. doi:10.7326/M19-2628
Vincent Mysliwiec, MD; Jennifer L. Martin, PhD; Christi S. Ulmer, PhD, DBSM; Susmita Chowdhuri, MD, MS; Matthew S. Brock, MD; Christopher Spevak, MD, MPH, JD; James Sall, PhD
This synopsis of a 2019 clinical practice guideline from the U.S. Department of Veterans Affairs and the U.S. Department of Defense addresses management of chronic insomnia disorder and obstructive sleep apnea.
Ann Intern Med. 2020;172(5):325-336. doi:10.7326/M19-3575
Mark Freedman, DVM, MPH; Andrew Kroger, MD, MPH; Paul Hunter, MD; Kevin A. Ault, MD; for the Advisory Committee on Immunization Practices
This article provides immunization recommendations from the Advisory Committee on Immunization Practices (ACIP) for adults aged 19 years or older. The ACIP-recommended use of each vaccine is determined after in-depth reviews of vaccine-related data, such as the epidemiology and burden of the vaccine-preventable disease, vaccine efficacy and effectiveness, vaccine safety, the quality of evidence, feasibility of program implementation, and economic analyses of immunization policy.
Ann Intern Med. 2020;172(5):337-347. doi:10.7326/M20-0046
Ameet Sarpatwari, PhD, JD; Alison K. LaPidus, MPH; Aaron S. Kesselheim, MD, JD, MPH
The high cost of many prescription drugs has renewed calls for policies to ensure that taxpayers' financial contributions to drug development are factored into price setting. The authors discuss lessons learned from a previous effort and how it may inform current discussions.
Ann Intern Med. 2020;172(5):348-350. doi:10.7326/M19-2576
Timothy Kelly, BA; Sara Brandspigel, MPH; Evan Polzer, MA; Marian E. Betz, MD, MPH
Preventing firearm-related injury and death requires pragmatic, community-based solutions. The authors describe their initial experiences developing a statewide map of locations where firearms may be temporarily stored away from the home when needed for safety.
Ann Intern Med. 2020;172(5):351-353. doi:10.7326/M19-2944
Ross L. Prentice, PhD
Current evidence about nutrition and health is largely from observational studies. A reliance on observational studies may be justified given the many important hypotheses related to the health benefits and risks of foods, nutrients, and dietary patterns, and the cost and logistic challenges of carrying out long-term randomized controlled dietary intervention trials to test such hypotheses. This commentary argues that among the many limitations of observational nutrition studies, measurement error is one of the most serious yet often ignored.
Ann Intern Med. 2020;172(5):354-355. doi:10.7326/M19-3290
Cathy C. Schubert, MD
Greeley and colleagues' systematic review highlighted the paucity of evidence on the effectiveness of sitters and alternatives to sitters in preventing falls among patients in acute care hospitals. The editorialist discusses the findings and argues that, for acute care hospitals to be truly effective at keeping patients safe from events, such as falls, we need to make the entire health system more age-friendly.
Ann Intern Med. 2020;172(5):356-357. doi:10.7326/M19-4005
Michelle M. Mello, JD, PhD
Delamater and colleagues projected the percentage of California schoolchildren with a vaccination exemption under 3 scenarios: California law as it has stood since the 2015 passage of Senate Bill 277, which permits medical but not personal belief exemptions; the law as amended by Senate Bill 276, an attempt to tighten the circumstances for medical exemptions; and a hypothetical world in which neither law was implemented. The editorialist discusses the findings and proposes 5 provisions that laws narrowing vaccination exemptions should include.
Ann Intern Med. 2020;172(5):358-359. doi:10.7326/M19-3111
Vincent Quagliarello, MD
Much is said about the virtue of the doctor's laying on of hands.
Ann Intern Med. 2020;172(5):360-361. doi:10.7326/M19-2093
Ann Intern Med. 2020;172(5):362-363. doi:10.7326/M19-1933
Ann Intern Med. 2020;172(5):363-365. doi:10.7326/L19-0486
Ann Intern Med. 2020;172(5):365-366. doi:10.7326/L19-0754
Ann Intern Med. 2020;172(5):366. doi:10.7326/L19-0755
Ann Intern Med. 2020;172(5):366-367. doi:10.7326/L19-0756
Ann Intern Med. 2020;172(5):367. doi:10.7326/L19-0757
Ann Intern Med. 2020;172(5):367. doi:10.7326/L19-0758
Ann Intern Med. 2020;172(5):367-368. doi:10.7326/L19-0743
Ann Intern Med. 2020;172(5):368. doi:10.7326/L19-0744
Matthew J. Bair, MD, MS; Erin E. Krebs, MD, MPH
Ann Intern Med. 2020;172(5):ITC33-ITC48. doi:10.7326/AITC202003030
Darren B. Taichman, MD, PhD
Ann Intern Med. 2020;172(5):ED5. doi:10.7326/AWED202003030
Robert M. Centor, MD; Kate Lally, MD
In this episode of Annals On Call, Dr. Centor discusses the concept of patients with cancer as fighters with Dr. Kate Lally. The learner will gain knowledge to fill knowledge gaps related to the care of and communication with patients who are facing cancer diagnoses.
Ann Intern Med. 2020;172(5):OC1. doi:10.7326/A19-0025
Grace E. Farris, MD
Dr. Mom explores the challenges and ups and downs of juggling life as a hospitalist and mother. The feature appears monthly in Annals Graphic Medicine at Annals.org.
Ann Intern Med. 2020;172(5):W69-W70. doi:10.7326/G20-0004
Caroline Shooner, MD; Tracy Morton, MD
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2020;172(5):W71-W72. doi:10.7326/G19-0026
Stefan Tigges, MD
Ann Intern Med. 2020;172(5):W73-W79. doi:10.7326/G19-0024
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