Josep Ordi-Ros, MD, PhD; Luis Sáez-Comet, MD, PhD; Mercedes Pérez-Conesa, MD; Xavier Vidal, MD, PhD; Antoni Riera-Mestre, MD, PhD; Antoni Castro-Salomó, MD, PhD; Jordi Cuquet-Pedragosa, MD; Vera Ortiz-Santamaria, MD; Montserrat Mauri-Plana, MD, PhD; Cristina Solé, PhD; Josefina Cortés-Hernández, MD, PhD
Long-term anticoagulation with vitamin K antagonists (VKAs) is the standard of care for preventing thrombosis in patients with antiphospholipid antibody syndrome (APS), but VKAs require frequent monitoring and are associated with food and drug interactions. This 3-year randomized controlled trial compared the efficacy and safety of a newer oral anticoagulant versus dose-adjusted VKAs in patients with APS.
Jennifer A. Watt, MD, PhD; Zahra Goodarzi, MD, MSc; Areti Angeliki Veroniki, PhD; Vera Nincic, PhD; Paul A. Khan, PhD; Marco Ghassemi, MSc; Yuan Thompson, PhD; Andrea C. Tricco, PhD; Sharon E. Straus, MD, MSc
This network meta-analysis of 163 randomized trials compares the efficacy of pharmacologic and nonpharmacologic interventions for treating aggression and agitation in adults with dementia.
Daniel S. Tawfik, MD, MS; Annette Scheid, MD; Jochen Profit, MD, MPH; Tait Shanafelt, MD; Mickey Trockel, MD, PhD; Kathryn C. Adair, PhD; J. Bryan Sexton, PhD; John P.A. Ioannidis, MD, DSc
This meta-analysis of 123 publications addresses relationships between health care provider burnout and quality of patient care.
Brad Spellberg, MD; Travis B. Nielsen, PhD; David N. Gilbert, MD; Andrew F. Shorr, MD, MPH, MBA; Eric P. Brass, MD, PhD
Current initiatives to incentivize development of antibiotics for resistant pathogens have yielded disappointing results because many recently approved antibiotics do not address clinical unmet needs or provide redundant coverage. In this article, the authors propose a different approach for guiding development of new antibiotics to combat resistant organisms.
Natalie A. Bello, MD, MPH; Eliza C. Miller, MD; Kirsten Lawrence Cleary, MD, MSc; Ronald Wapner, MD
Cardiovascular disease is the leading cause of death among women in the United States, and stroke is third. This article discusses female-specific cardiovascular risk factors across the lifespan and describes a precision medicine–based approach to risk factor modification and primary prevention, including the current role of genetic testing in the assessment of risk for cardiovascular disease and stroke.
Denis Wahl, MD, PhD; Virginie Dufrost, MD
Ordi-Ros and colleagues have reported results of a randomized trial comparing rivaroxaban with dose-adjusted vitamin K antagonist therapy for patients with thrombotic antiphospholipid antibody syndrome (APS). The editorial discusses the results of the trial in the context of previous data and concludes that direct oral anticoagulants should not be prescribed in the setting of high-risk APS.
Carolyn S. Dewa, MPH, PhD; Karen Nieuwenhuijsen, PhD; Jeffrey S. Hoch, PhD
The editorialists discuss Tawfik and coworkers' findings and highlight future approaches that might provide a deeper understanding of the interplay between clinician burnout and quality of care.
Avik Chatterjee, MD, MPH
Kate Lally, MD
Lynette Lamp, MD
Geno J. Merli, MD; Howard H. Weitz, MD
Annals Consult Guys brings a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Darren B. Taichman, MD, PhD
David H. Wesorick, MD; Vineet Chopra, MD, MSc
Duminda N. Wijeysundera, MD, PhD; Karim S. Ladha, MD, MSc
Assessment of functional capacity is generally considered to be an integral part of preoperative risk stratification for major surgery. Here, the authors weigh the pros and cons of unstructured questions and objective measures to identify a patient's presurgical risk for cardiovascular events and death.
Robert M. Centor, MD; Reem A. Mustafa, MD, MPH, PhD
In this episode of Annals On Call, Dr. Centor discusses screening for breast cancer with Dr. Reem A. Mustafa of the University of Kansas.
Michael Natter, MD
Progress Notes explores the everyday emotional, clinical, humorous, and ethical challenges of the medical residency training process. It appears monthly in Annals Graphic Medicine at Annals.org.
Jaffer Shah; Raida Shah, MD
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Randol W. Hooper II, MBBS, MS; Jamie L. Garfield, MD
In the context of the emergence of vaping-associated pulmonary injury (VAPI), this commentary discusses what we know about the health effects of vaping and, more important, what we need to learn. Research on the respiratory toxicity of vaporized e-cigarette compounds and cannabis extracts, population studies on consumption patterns, and increased physician attention are urgently needed to mitigate the effects of VAPI.
Y. Dana Neugut, MD, MS; Sumit Mohan, MD, MPH; Ali G. Gharavi, MD; Krzysztof Kiryluk, MD, MS
This article discusses possible indications for genetic testing in a patient with chronic kidney disease being assessed for a potential kidney transplant. The authors discuss whether genetic testing, including APOL1 testing in persons of African ancestry, has a role in the evaluation of prospective transplant recipients and potential living donors.
John R. Stone, MD, PhD
Steinberg and colleagues report high but slowly declining U.S. mortality trends in patients with antineutrophil cytoplasmic autoantibody–associated vasculitides. The editorialist discusses the findings and why he believes that the apparently better outcomes observed in typically disadvantaged patient groups may hold clues to structural causes of health disparities.
Jing Luo, MD, MPH; Martin Kulldorff, PhD; Ameet Sarpatwari, JD, PhD; Ajinkya Pawar, PhD; Aaron S. Kesselheim, MD, JD, MPH
Studies suggest that drug prices vary widely across retail pharmacies. In this study, researchers used drug pricing data from GoodRx to describe cash prices across categories of retail pharmacies throughout the United States for commonly used generic and brand-name drugs.
Dena Zeraatkar, MSc; Bradley C. Johnston, PhD; Jessica Bartoszko, HBSc; Kevin Cheung, MD; Malgorzata M. Bala, MD, PhD; Claudia Valli, MSc; Montserrat Rabassa, PhD; Daegan Sit, MD; Kirolos Milio, BSc; Behnam Sadeghirad, PharmD; Arnav Agarwal, MD; Adriana M. Zea, RD; Yung Lee, BHSc; Mi Ah Han, MD, PhD; Robin W.M. Vernooij, PhD; Pablo Alonso-Coello, MD, PhD; Gordon H. Guyatt, MD; Regina El Dib, PhD
This systematic review of 12 randomized trials examines the effect of lower versus higher red meat intake on the incidence of cancer and cardiovascular outcomes in adults.
Claudia Valli, MSc; Montserrat Rabassa, PhD; Bradley C. Johnston, PhD; Ruben Kuijpers, MSc; Anna Prokop-Dorner, PhD; Joanna Zajac, PhD; Dawid Storman, MD; Monika Storman, MD; Malgorzata M. Bala, MD, PhD; Ivan Solà, MSc; Dena Zeraatkar, MSc; Mi Ah Han, MD, PhD; Robin W.M. Vernooij, PhD; Gordon H. Guyatt, MD; Pablo Alonso-Coello, MD, PhD; for the NutriRECS Working Group
This systematic review evaluates evidence about people's preferences and values regarding meat consumption.
Robin W.M. Vernooij, PhD; Dena Zeraatkar, MSc; Mi Ah Han, MD, PhD; Regina El Dib, PhD; Max Zworth, BA⪼ Kirolos Milio, BSc; Daegan Sit, MD; Yung Lee, BHSc; Huda Gomaa, MSc; Claudia Valli, MSc; Mateusz J. Swierz, MD; Yaping Chang, PhD; Steven E. Hanna, PhD; Paula M. Brauer, PhD, RD; John Sievenpiper, MD, PhD; Russell de Souza, RD, ScD; Pablo Alonso-Coello, MD, PhD; Malgorzata M. Bala, PhD; Gordon H. Guyatt, MD, MSc; Bradley C. Johnston, PhD
This systematic review of 70 large prospective cohort studies examines the effect of dietary patterns of meat consumption on cardiovascular, cancer, and mortality outcomes.
Dena Zeraatkar, MSc; Mi Ah Han, MD, PhD; Gordon H. Guyatt, MD, MSc; Robin W.M. Vernooij, PhD; Regina El Dib, PhD; Kevin Cheung, MD, MSc; Kirolos Milio, BSc; Max Zworth, BASc; Jessica J. Bartoszko, HBSc; Claudia Valli, MSc; Montserrat Rabassa, PhD; Yung Lee, BHSc; Joanna Zajac, PhD; Anna Prokop-Dorner, PhD; Calvin Lo, BHSc; Malgorzata M. Bala, PhD; Pablo Alonso-Coello, MD, PhD; Steven E. Hanna, PhD; Bradley C. Johnston, PhD
This systematic review of 55 large cohort studies examines associations between red meat consumption and mortality, stroke, myocardial infarction, and diabetes.
Mi Ah Han, MD, PhD; Dena Zeraatkar, MSc; Gordon H. Guyatt, MD; Robin W.M. Vernooij, PhD; Regina El Dib, PhD; Ying Zhang, PhD; Abdullah Algarni, MBBS; Gareth Leung, BHSc; Dawid Storman, MD; Claudia Valli, MSc; Montserrat Rabassa, PhD; Nadia Rehman, BDS; Michael K. Parvizian, BHSc; Max Zworth, BA⪼ Jessica J. Bartoszko, HBSc; Luciane Cruz Lopes, PhD; Daegan Sit, MD; Malgorzata M. Bala, MD, PhD; Pablo Alonso-Coello, MD, PhD; Bradley C. Johnston, PhD
This systematic review of 56 large cohort studies examines a possible causal relation between red and processed meat and cancer mortality and incidence.
Bradley C. Johnston, PhD; Dena Zeraatkar, MSc; Mi Ah Han, PhD; Robin W.M. Vernooij, PhD; Claudia Valli, MSc; Regina El Dib, PhD; Catherine Marshall; Patrick J. Stover, PhD; Susan Fairweather-Taitt, PhD; Grzegorz Wójcik, PhD; Faiz Bhatia, PEng; Russell de Souza, ScD; Carlos Brotons, MD, PhD; Joerg J. Meerpohl, MD; Chirag J. Patel, PhD; Benjamin Djulbegovic, MD, PhD; Pablo Alonso-Coello, MD, PhD; Malgorzata M. Bala, MD, PhD; Gordon H. Guyatt, MD
These guidelines from a Nutritional Recommendations (NutriRECS) Consortium address evidence-based recommendations concerning consumption of red meat and processed meat in adults.
Rena M. Conti, PhD
In their article, Luo and colleagues examine variation by pharmacy type and ZIP code in the prices of 6 on-patent and 10 off-patent (generic) prescription drugs throughout the United States in 2015. The editorialist discusses the findings and raises concerns about the data the study used.
Aaron E. Carroll, MD, MS; Tiffany S. Doherty, PhD
This issue includes 5 systematic reviews and new recommendations regarding consumption of red and processed meat and health outcomes. The editorialists discuss the findings and the insight they offer regarding why many have not changed their dietary habits despite prior recommendations to reduce meat consumption.
Reinier G.S. Meester, PhD; Iris Lansdorp-Vogelaar, PhD; Sidney J. Winawer, MD, DSc; Ann G. Zauber, PhD; Amy B. Knudsen, PhD; Uri Ladabaum, MD, MS
Robust evidence suggests that screening substantially reduces risk for death due to colorectal cancer through removal of precancerous adenomas and early detection, but few outcome data exist to inform appropriate management of patients in whom adenomas have been removed. In this study, the authors used a microsimulation model to compare the lifetime benefits and costs of high- versus low-intensity surveillance among patients with low- or high-risk adenomas removed after screening with colonoscopy or fecal immunochemical testing.
David S. Weinberg, MD, MSc; Robert E. Schoen, MD, MPH
In this issue, Meester and colleagues use microsimulation modeling to assess the cost-effectiveness of high- and low-intensity surveillance colonoscopy in patients with adenomas. The editorialists discuss the findings, unanswered questions about the benefit of surveillance, and the issue of optimal resource use.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use