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Biographies of Annals Staff

Editor in Chief

Christine Laine, MD, MPH

Christine Laine, MD, MPHChristine Laine, MD, MPH, is Editor in Chief of Annals of Internal Medicine. She is a practicing physician in Philadelphia and is board-certified in internal medicine. Dr. Laine is a Clinical Associate Professor in the Division of Internal Medicine at Jefferson Medical College. Dr. Laine first joined Annals of Internal Medicine in June 1995 as an Associate Editor and became a Deputy Editor in 1998 and Senior Deputy Editor in April 2008. In July 2009, Dr. Laine became the Editor in Chief and a Senior Vice President at the American College of Physicians.

Dr. Laine graduated summa cum laude, with a double major in biology and writing, from Hamilton College in Clinton, New York. She received her medical degree from State University of New York at Stony Brook and completed residency training in internal medicine at The New York Hospital (Cornell University) and a fellowship in general internal medicine and clinical epidemiology at Beth Israel Hospital (Harvard University). Dr. Laine earned her master of public health degree, with a concentration in quantitative methods and clinical epidemiology, at Harvard University.

Dr. Laine is active in the world of medical journalism and holds leadership positions in the International Committee of Medical Journal Editors, the Council of Science Editors, and the Ethics committee of the World Association of Medical Editors. She has been instrumental in the development of editorial policy about such issues as authorship and conflicts of interest in medical research.

Executive Editor

Darren B. Taichman, MD, PhD

Darren B. Taichman, MD, PhDDarren Taichman is Executive Editor of Annals of Internal Medicine. He practices Pulmonary and Critical Care medicine, specializing in pulmonary vascular disease, at the University of Pennsylvania, where he is an Adjunct Associate Professor of Medicine. Dr. Taichman first joined Annals of Internal Medicine as Associate Editor for Pulmonary and Critical Care Medicine in 2007. He became a Deputy Editor in 2009 and Executive Deputy Editor in 2010.

Dr. Taichman earned his bachelor's degree in 1982, a PhD in Pathology in 1992, and an MD in 1993 from the University of Pennsylvania. He completed residency training in Internal Medicine at Harvard's Beth Israel Hospital, Boston, and Pulmonary and Critical Care Fellowships at the Hospital of the University of Pennsylvania. He completed research fellowships in vascular biology at the Brigham and Women's Hospital, Boston, and the Children's Hospital of Philadelphia. He joined the faculty of the University of Pennsylvania in 2000 as the Director of the Medical Intensive Care Unit at Penn Presbyterian Medical Center and Associate Director of Penn's Pulmonary Vascular Disease Program. His research has focused in endothelial cell biology and the epidemiology of pulmonary arterial hypertension. He joined the Education and Publication Division of the American College of Physicians in 2007 as a Senior Medical Associate.

In addition to his work at Annals, Dr. Taichman is active in national and international leadership positions within the American College of Chest Physicians, the Pulmonary Hypertension Association, and the International Committee of Medical Journal Editors.

Senior Deputy Editor

Cynthia D. Mulrow, MD, MSc

Cynthia D. Mulrow, MD, MScCindy is Senior Deputy Editor of Annals of Internal Medicine and Clinical Professor of Medicine at the University of Texas Health Science Center at San Antonio. She has been Program Director of the Robert Wood Johnson Foundation Generalist Physician Faculty Scholars Program and Director of the San Antonio Cochrane Collaboration Center and the San Antonio Evidence-based Practice Center. She was elected to the American Society of Clinical Investigation in 1997, honored as a Master of the ACP in 2005, and elected to the Institute of Medicine in 2008.

Cindy's academic work followed several themes including systematic reviews, research methodology, and chronic medical conditions. She has authored numerous papers and served on guideline panels including the U.S. Preventive Services Task Force. She currently contributes to groups who set standards for reporting research: PRISMA (systematic reviews and meta-analyses), STROBE (observational studies), and CONSORT (clinical trials). She is an amateur decorator, a gardener without a green thumb, and an avid but flagging runner and swimmer.

Deputy Editors

Jaya K. Rao, MD, MHS

Jaya K. Rao, MD, MHSJaya Rao received a BSc in Microbiology (with high honors) and MD from the University of Florida. She completed her internal medicine residency at the University of Virginia Hospitals and rheumatology fellowship at Duke University Medical Center. During her rheumatology fellowship, she also completed a health services research fellowship at the Durham Veterans Affairs Medical Center and received a master of health science from Duke University. Dr. Rao has served as a faculty member at Indiana University, Duke University, and the University of North Carolina at Chapel Hill, and she worked as a medical epidemiologist/health services researcher in the Chronic Disease Center at the Centers for Disease Control and Prevention for 8 years. She is a board-certified rheumatologist who has practiced in rheumatology and/or internal medicine clinics since completing her fellowship.

Dr. Rao's primary research interests are in the areas of patient–provider relationship (primarily, patient–provider communication), use of diagnostic testing for musculoskeletal conditions, and chronic disease epidemiology. She has particular expertise conducting longitudinal cohort studies and systematic reviews. Dr. Rao is currently a member of the Literature Selection and Technical Review Committee for the National Library of Medicine. This committee evaluates and makes recommendations regarding biomedical publications to be considered for indexing and inclusion in Medline.


Christina C. Wee, MD, MPH

Christina C. Wee, MD, MPHDr. Wee is Associate Professor of Medicine at Harvard Medical School and Director of the Obesity Research Program in the Division of General Medicine at Beth Israel Deaconess Medical Center (BIDMC). She is also the Associate Program Director for the Internal Medicine Program at BIDMC and former Program-Director of the Harvard-wide General Medicine Faculty Development Fellowship Program (2006–2018). She is a board-certified internist with more than 20 years' experience as a practicing primary care clinician. She currently serves on the Board of Directors for Harvard Medical Faculty Physicians at BIDMC.

Dr. Wee graduated with a BS in chemistry from Ursinus College in 1989 and received her MD from Jefferson Medical College in 1994. She completed her residency at the University of Texas Southwestern in 1997, and General Medicine Fellowship at the Harvard Combined Fellowship Program in 1999 when she also received her MPH degree in clinical effectiveness from the Harvard T.H. Chan School of Public Health. Dr. Wee's research focuses on obesity, health disparities, and patient preferences and decision making in the context of weight treatment and primary care. Her work has been funded by numerous foundation and NIH grants and leverages a combination of research methods, including survey research, development of epidemiologic cohorts, clinical interventions, and analyses of large complex national data sets. An outstanding investigator and mentor, Dr. Wee was inducted into the American Society for Clinical Investigation in 2012 and is the recipient of several regional and national awards, including the 2011 Midcareer Research and Mentorship Award from the Society of General Internal Medicine. Dr. Wee's editorial experience includes being a former Deputy Editor and member of the Board of Directors for the Journal of General Internal Medicine and a former Associate Editor for JAMA Internal Medicine.

Sankey V. Williams, MD

Sankey V. Williams, MDDr. Williams is Sol Katz Professor of General Internal Medicine and Professor of Health Care Management in the Wharton School at the University of Pennsylvania. He was Director of the Robert Wood Johnson Foundation's Clinical Scholars Program there from 1988 to 1996, and he was Chief of the Division of General Internal Medicine from 1992 to 2008.

Dr. Williams has published more than 60 original articles that describe his work as a health services researcher, which has concentrated on physicians' decisions to use clinical resources, often regarding the use of diagnostic tests. His work also has focused on patient classification systems used by researchers to adjust outcomes for severity of illness.

Dr. Williams was Chair of one of four study Sections at the Agency for Health Care Policy and Research from 1990 to 1994. He is a former President of the Society for Medical Decision Making, and he has given invited lectures to numerous professional and scientific audiences here and abroad. He was appointed Commissioner on the U.S. Congress's Prospective Payment Assessment Commission, which advised Congress about changes in Medicare payments to hospitals. He has had leadership roles in the Society of General Internal Medicine, including Editor of the Journal of General Internal Medicine (1995–1999), President of the Society (2000–2001), and recipient of the Society's 2008 Robert J. Glaser Award for exceptional contributions in education and research.

Yu-Xiao Yang, MD, MSCE

Yu-Xiao Yang, MDYu-Xiao Yang, MD, MSCE, is Associate Professor of Medicine and Epidemiology in the Department of Medicine, and a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania. He is also a staff gastroenterologist at the Corporal Michael J. Crescenz VA Medical Center and a core investigator of the Center for Health Equity Research and Promotion, a VA HSR&D Center of Innovation. He is board-certified in internal medicine and gastroenterology. Dr. Yang first joined Annals of Internal Medicine as Associate Editor in 2006 and became a Deputy Editor in 2019.

Dr. Yang graduated summa cum laude from the City College of New York in 1992 with a major in electrical engineering. He subsequently received his MD from the New York University School of Medicine in 1996. He was then recruited to the internal medicine residency program at the University of Pennsylvania. He subsequently underwent gastroenterology fellowship training at Penn from 1999 to 2002. During his fellowship, he acquired an MSCE degree from the University of Pennsylvania.

Dr. Yang has developed an active and independent research program in GI cancer epidemiology and GI pharmacoepidemiology. His research program has been continuously supported by highly competitive venues, including the NIH, AHRQ, VA, and GI foundations and has yielded numerous peer-reviewed original research publications. In addition, as a member of the American Gastroenterological Association (AGA) Clinical Practice and Quality Management committee, he served on a number of AGA evidence-based guideline panels. Dr. Yang also previously served as Associate Editor for Pharmacoepidemiology and Drug Safety, the official journal of the International Society of Pharmacoepidemiology.

Associate Editors

Victor Adlin, MD, received a BA in biology and an MD both at Temple University in Philadelphia. He completed an NIH-sponsored Fellowship in Endocrinology at Temple University School of Medicine. He has been an Assistant Editor/Associate Editor at Annals of Internal Medicine since 1974. He was Associate Editor for the Subspecialty Medical Knowledge Self-Assessment Program in Endocrinology and Diabetes (MKSAP-ED) of the ACP, 1992–1994. He is the author of a book Endocrinology Science and Medicine (Lippincott Williams and Wilkins, 2002) and has authored the section on Endocrine and Metabolic Diseases in the textbook Medicine (Myers AR Editor, Lippincott Williams and Wilkins, 1986 to 2001). His research interests have been in the area of endocrine hypertension, especially low-renin hypertension. He practices clinical endocrinology and is Associate Professor Emeritus at Temple University School of Medicine.

Michael Bretthauer, MD, PhD, is professor of medicine at the University of Oslo and gastroenterologist at Oslo University Hospital. Dr. Bretthauer is president of the Frontier Science Foundation in Boston, and a guest research at the Harvard School of Public Health. He received his MD in 1996 from the University of Gottingen, Germany, and and his PhD from the University of Oslo, Norway, in 2004. He is board certified in internal medicine and gastroenterology. His main clinical activities are in gastrointestinal endoscopy. Dr. Bretthauer's main research interests include clinical trials and clinical epidemiology. He is chairing several large-scale international trials in colorectal cancer screening and surveillance, such as the Nordic-European Initiative on Colorectal Cancer and the European Polyp Surveillance trials. Dr. Bretthauer served as an associate editor at the Norwegian Medical Journal from 2004 to 2011, and as an editorial fellow and CME editor at the New England Journal of Medicine from 2008 to 2010.

Steven N. Goodman, MD, PhD, MHS, has been a statistical and Associate Editor at Annals of Internal Medicine since 1987, serving under 5 editors. He is Associate Dean for Clinical and Translational Research and Professor of Medicine and Health Research and Policy at Stanford University School of Medicine, where he directs the CTSA training programs in clinical research and co-directs METRICS (Meta-Research Innovation Center at Stanford), a new center focused on studying and improving the validity of published medical research. Before moving to Stanford in 2011, he was on the Johns Hopkins faculty for over 2 decades, in the oncology center's division of Biostatistics and Bioinformatics, which he directed for 3 years, and co-directed the doctoral program in the Department of Epidemiology for a decade. He was editor-in-chief of the journal Clinical Trials from 2004 to 2013. He is scientific advisor to the Blue Cross-Blue Shield Technology Assessment program and is Vice Chair of the PCORI Methodology Committee. He has served on large number of IOM committees, including co-chairing the 2011 committee commissioned by the FDA on "Scientific and Ethical Issues in Studying the Safety of Approved Drugs," and most recently serving on a committee on "Responsible Sharing of Clinical Trial Data." He received an AB from Harvard, majoring in Applied Mathematics and Biochemistry, an MD from NYU, trained in Pediatrics at Washington University in St. Louis, in which he was board-certified, and received an MHS in Biostatistics and PhD in Epidemiology from Johns Hopkins School of Public Health.

Michael E. Griswold, PhD, is Professor and Director of the Center of Biostatistics and Bioinformatics at the University of Mississippi Medical Center. He also holds adjunct faculty appointments in the departments of Biostatistics at Johns Hopkins School of Public Health, where he received his PhD, as well as the University of Alabama at Birmingham School of Public Health. Dr. Griswold's methodological research focuses on translational biostatistics and multilevel/longitudinal models for complex data archetypes, and he has extensive experience in the design, execution, and analysis of observational and experimental studies.

Eliseo Guallar, MD, MPH, DrPH, is Professor of Epidemiology and Medicine at the Johns Hopkins University Bloomberg of Public Health, and a core faculty member of the Welch Center for Prevention, Epidemiology, and Clinical Research of the Johns Hopkins Medical Institutions in Baltimore. Dr. Guallar obtained his MD at the University of Zaragoza (Spain), and trained in epidemiology at the University of Minnesota (Minneapolis) and the Harvard School of Public Health (Boston), where he obtained a doctor of public health degree. Dr. Guallar's main fields of interest are cardiovascular disease epidemiology and the development and application of statistical methods to epidemiological and clinical research. He is conducting several population studies on the association of environmental and dietary exposures with cardiovascular risk. Dr. Guallar is also involved in studying the determinants of sudden cardiac death in low-risk and high-risk populations and in evaluating the trajectories of cardiovascular and metabolic risk factors in a large cohort of Korean men and women attending annual health exams. Dr. Guallar has also substantial experience in the conduct of systematic reviews and meta-analyses of observational studies and of randomized clinical trials. Dr. Guallar has published more than 200 papers in peer-reviewed journals. At the Johns Hopkins Bloomberg School of Public Health, Dr. Guallar teaches environmental epidemiology and epidemiological methods. Dr. Guallar has served in numerous review panels for the National Institutes of Health and the American Heart Association, and is an associate editor of Annals of Internal Medicine and Environmental Health Perspectives.

DuPont Guerry IV, MD, has a BA (English) from Yale and an MD from the University of Virginia. After a residency in Medicine at the Boston City Hospital, he studied host defense mechanisms and clinical infectious diseases at the National Institutes of Health. He did a fellowship in hematology and oncology at the University of Pennsylvania, whose faculty he joined in 1975. His clinical work extended from cutaneous oncology to benign and malignant hematology, and his teaching included serving as director of the hematology-oncology fellowship. As an Emeritus Professor of the University of Pennsylvania, his investigative career continues to be focused on melanoma as a paradigm of the biological, epidemiological, and clinical expression of tumor progression. He was an assistant editor of Cancer Research and has been an Associate Editor of Annals of Internal Medicine since 2000.

William G. Kussmaul III, MD, received an undergraduate degree in physics from Yale College and his MD from the University of Pennsylvania School of Medicine. After service in the U.S. Navy, he completed advanced cardiology training at the Hospital of the University of Pennsylvania in 1985 and has practiced invasive and interventional cardiology in the Philadelphia area ever since. He is an Associate Professor at Drexel University College of Medicine, and director of the Cardiac Catheterization Laboratories at Hahnemann University Hospital. He has been an Associate Editor at Annals of Internal Medicine since 1995.

Michael A. LaCombe, MD, is the Associate Editor for the "On Being a Doctor," "On Being a Patient," and "Ad Libitum" sections of Annals of Internal Medicine. He has published more than 100 stories and essays in peer-reviewed medical journals, as well as 13 books. A collection of his stories, Bedside: The Art of Medicine, was published by the University of Maine Press in 2010. The American College of Physicians presented the Nicholas E. Davies Memorial Scholar Award for Scholarly Activities in the Humanities and History of Medicine to Dr. LaCombe in April 2011. He received an Honorary Doctorate of Humane Letters from the University of Southern Maine in May 2012. He has recently been elected President-elect of the Harvard Medical Alumni Association. Dr. LaCombe has practiced internal medicine and cardiology in Maine since 1975 and continues to work full-time.

A. Russell Localio, JD, MPH, MS, received undergraduate and then graduate degrees in economics from Columbia University and Michigan State University, an MS in biostatistics and an MPH (public health) from Harvard, and a PhD from the University of Pennsylvania. After serving as a research associate at Harvard and on the faculty of biostatistics at Penn State University, Hershey, he joined the faculty, now as an Associate Professor, in the Department of Biostatistics and Epidemiology at University of Pennsylvania Perelman School of Medicine. In addition to an extensive ongoing portfolio of collaborative research in internal medicine, infectious diseases, and pediatrics, he teaches a 2-semester graduate course in longitudinal data.

Lisa A. Mandl, MD, MPH, received an undergraduate degree from Williams College and received her medical degree from the University of British Columbia. She subsequently completed a residency in internal medicine at the University of British Columbia, followed by a fellowship in rheumatology at The Brigham and Women's Hospital/Harvard Medical School in Boston. She also received a master's degree in public health from the Harvard School of Public Health. Her research focus is on inflammatory and osteoarthritis, including predictors of outcomes after total joint replacement. Dr. Mandl currently works as a clinical investigator and rheumatologist at Hospital for Special Surgery/Weill Cornell Medical School in New York City.

Anne R. Meibohm, PhD, received a BS in mathematics and biology from Valparaiso University (Indiana) and an MS and PhD in Biostatistics from the University of North Carolina at Chapel Hill. She worked in the pharmaceutical industry for more than 25 years and contributed statistical expertise to the design and analysis of clinical trials in a variety of therapeutic areas, including HIV/AIDS, other infectious diseases, cardiovascular disease, and hematology/oncology. Dr. Meibohm has been an Associate Statistical Editor for Annals of Internal Medicine since March 2009.

Anita Palepu, MD, MPH, completed her medical degree at McMaster University, her internal medicine residency at Queen's University, and her general internal medicine fellowship and master's in public health degree from Boston University. She is a Professor of Medicine at the University of British Columbia, and her research area is in urban health, particularly housing, homelessness, and health. Along with her work as Associate Editor with Annals of Internal Medicine, she works as attending staff on the Clinical Teaching Unit at St. Paul's Hospital, Vancouver, British Columbia.

Mindy G. Schuster, MD, MSCE, received a BA in English and the biologic basis of behavior, and a master's in clinical epidemiology and biostatistics from the University of Pennsylvania. She got her MD from Yale University and did a residency in internal medicine at New York Hospital/Cornell Medical Center and then a fellowship in infectious disease at the University of Pennsylvania. She is a Professor of Medicine/Infectious Disease at the University of Pennsylvania, where her clinical and research focus is in infections in patients with hematologic malignancy, stem cell transplantation, and invasive fungal infections.

Jodi B. Segal, MD, MPH, is a Professor of Medicine at the Johns Hopkins University School of Medicine, where she practices general internal medicine. She also has appointments in the Bloomberg School of Public Health in the Departments of Health Policy and Management and in Epidemiology. She has been a leader in comparative effectiveness research nationally. She is an associate director of the Center for Health Services and Outcomes Research, where she works closely with students and faculty doing outcomes research using large data sets, and is the co-director of the Center for Drug Safety and Effectiveness at Johns Hopkins. She serves on the Medicare Evidence Development and Coverage Advisory Committee (MEDCAC) and is an ad hoc member of the FDA's Drug Safety and Risk Management Advisory Committee. Her medical degree is from the University of Pittsburgh School of Medicine and her MPH is from Johns Hopkins Bloomberg School of Public Health.

Ashwini Sehgal, MD, is the Duncan Neuhauser Professor of Community Health Improvement and Director of the Center for Reducing Health Disparities at Case Western Reserve University in Cleveland, Ohio. He is also Professor of Medicine, Biomedical Ethics, and Epidemiology and Biostatistics at Case Western Reserve University. In addition, he is a practicing nephrologist at MetroHealth Medical Center. Dr. Sehgal received his bachelor's degree in mathematics, summa cum laude, from the University of Rochester, and his MD from Harvard Medical School. He then completed an internship and residency in internal medicine at Massachusetts General Hospital and a nephrology fellowship while participating in the Robert Wood Johnson Clinical Scholars Program at the University of California, San Francisco. His active research interests include health disparities, access to kidney transplantation, quality of care, and renal nutrition.

Michael Unger, MD, is an expert in the field of lung cancer and was an early pioneer in the field of interventional bronchoscopy. His experience includes serving at Fox Chase Cancer Center in Philadelphia as a professor and director of the pulmonary cancer detection and prevention program and as the director of the pulmonary endoscopy and high-risk lung cancer program. Dr. Unger has also served on the faculty of the University of Pennsylvania and Jefferson University and is a fellow of many national and international professional organizations. He is an author of numerous original medical articles and textbook publications and a sought-after participant in domestic and international educational conferences and seminars. He received his MD magna cum laude from the University of Bordeaux (France). His postgraduate education in the U.S. included his internship and residency in internal medicine at Wayne State University in Detroit and Mount Sinai Hospital-Elmhurst in New York City. He completed his pulmonary and critical care fellowship at New York Hospital-Cornell. He is board-certified in internal medicine, pulmonary diseases, and critical care. Dr. Unger is a member of guidelines committees on lung cancer (ACCP) and screening for lung cancer (NCCN). His additional interests are in applications of new technologies in medicine, medical education, and bioethics. He has previously served on several editorial boards, including Chest, Journal of Bronchology, Lasers in Medicine and Surgery, and the Polish Journal of Pulmonary Diseases. Since 2009, he has served as an Associate Editor for Annals of Internal Medicine.

John B. Wong, MD, is Chief of the Division of Clinical Decision Making at Tufts Medical Center, Director of Comparative Effectiveness Research at Tufts CTSI, and Professor of Medicine at Tufts University School of Medicine. He received a BS with Honors in Biology from Haverford College and an MD from the University of Chicago and trained in internal medicine and clinical decision making at Tufts Medical Center. A past president of the Society for Medical Decision Making, a member of the USPSTF and co-chair of the Physician Consortium for Performance Improvement Preventive Care Technical Expert Panel, he has been a Statistical Consultant/Associate Statistical Editor at the Annals of Internal Medicine since 2005. Dr. Wong's research focuses on the application of decision analysis to help patients, physicians, and policymakers choose among alternative tests, treatments, and policies, thereby promoting rational evidence-based efficient and effective patient-centered care. Besides participating in numerous consensus conferences, guidelines, and appropriateness use criteria assessments, he has published over 200 articles, co-authored Learning Clinical Reasoning and Decision Making in Health and Medicine, has been a member of the NAM Committee on Diagnostic Error in Health Care, and has developed award-winning decision aids for shared decision making with the Informed Medical Decisions Foundation.


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